Ascorbic Acid Supplementation Does Not Alter Oxidative Stress Markers in Healthy Volunteers Engaged in a Supervised Exercise Program.

The purpose of this study was to investigate the impact of ascorbic acid (AA) consumption on the oxidative stress status of untrained volunteers participating in a supervised exercise program. The study included 46 young adults (average age 23.5±0.59 years; 37 females, 9 males) who remained sedentary (sedentary 0AA, n=16) or participated in 30 min of outdoor aerobic running (n=30) at intensity corresponding to 65-75% of maximum heart rate three times per week for 12 weeks. Exercised subjects were randomly assigned to exercise group without ascorbic acid supplementation (control 0AA, n=10) or received either 250 mg (250AA, n=10) or 500 mg (500AA, n=10) previous to each exercise session. Blood samples were taken on day 0 and day 84 to evaluate metabolic profiles and antioxidant status. Sedentary subjects underwent in a single bout aerobic running to determine total antioxidant status (TAS) and malondiadehyde (MDA) at pre- and post-exercise with or without AA supplementation. No significant change in TAS was observed. Plasma MDA significantly increased at post-exercise (PThe accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author