Our current understanding of pituitary adenoma (PA) pathobiology is limited. Thus, the purpose of this project is to gain a better understanding of PA biology through the completion of two aims: 1) conducting a retrospective review of PA patients and 2) establishing and characterizing an intracranial xenograft mouse model of PA and using the model to identify novel targeted therapies. With respect to our first aim, several tumor- and patient specific factors were correlated to PA growth and recurrence. In our second aim, our tumor models were found to express growth hormone (GH) and prolactin as well as proteins in the mTOR pathway. These PA models were responsive to mTOR inhibition using RAD001 and resuted in a reduction in tumor growth ...
Background: Gigantism and acromegaly are the main consequences of GH excess, mainly due to a pituita...
BACKGROUND: Pituitary adenomas are common intracranial neoplasms, comprising 10 - 15% of all brain t...
Pituitary tumors are frequently encountered intracranial neoplasms. They present with a variety of c...
Our current understanding of pituitary adenoma (PA) pathobiology is limited. Thus, the purpose of t...
Pituitary adenomas make up to 10-15% of all intracranial tumors. Pos-mortem exams have found them in...
Pituitary adenomas make up to 10-15% of all intracranial tumors. Pos-mortem exams have found them in...
International audienceAbstract Pituitary adenomas (PAs) are neoplasms derived from the endocrine cel...
Pituitary tumors account for about 15 % of primary intracranial neoplasms.1 Given the critical locat...
In recent years the demonstration that human pituitary adenomas are monoclonal in origin provides fu...
Tumors of the pituitary gland are frequent intracranial neoplasms. They can affect all ages and show...
Pituitary adenomas cause significant endocrine and mass-related morbidity. Only little is known abou...
In recent years, the demonstration that human pituitary adenomas are monoclonal provides further sup...
The review assesses immunohistochemical findings of somatostatin receptors and of metalloproteinases...
Pituitary tumors are common in the general population. Since neuroimaging techniques have improved, ...
The chapter focuses on understanding the latest classification of the pituitary adenomas in light of...
Background: Gigantism and acromegaly are the main consequences of GH excess, mainly due to a pituita...
BACKGROUND: Pituitary adenomas are common intracranial neoplasms, comprising 10 - 15% of all brain t...
Pituitary tumors are frequently encountered intracranial neoplasms. They present with a variety of c...
Our current understanding of pituitary adenoma (PA) pathobiology is limited. Thus, the purpose of t...
Pituitary adenomas make up to 10-15% of all intracranial tumors. Pos-mortem exams have found them in...
Pituitary adenomas make up to 10-15% of all intracranial tumors. Pos-mortem exams have found them in...
International audienceAbstract Pituitary adenomas (PAs) are neoplasms derived from the endocrine cel...
Pituitary tumors account for about 15 % of primary intracranial neoplasms.1 Given the critical locat...
In recent years the demonstration that human pituitary adenomas are monoclonal in origin provides fu...
Tumors of the pituitary gland are frequent intracranial neoplasms. They can affect all ages and show...
Pituitary adenomas cause significant endocrine and mass-related morbidity. Only little is known abou...
In recent years, the demonstration that human pituitary adenomas are monoclonal provides further sup...
The review assesses immunohistochemical findings of somatostatin receptors and of metalloproteinases...
Pituitary tumors are common in the general population. Since neuroimaging techniques have improved, ...
The chapter focuses on understanding the latest classification of the pituitary adenomas in light of...
Background: Gigantism and acromegaly are the main consequences of GH excess, mainly due to a pituita...
BACKGROUND: Pituitary adenomas are common intracranial neoplasms, comprising 10 - 15% of all brain t...
Pituitary tumors are frequently encountered intracranial neoplasms. They present with a variety of c...