Effects of sex steroids on components of the insulin resistance syndrome in transsexual subjects
- Elbers, J.M.H.
- Giltay, E.J.
- Teerlink, T.
- Scheffer, P.G.
- Asscheman, H.
- Seidell, J.C.
- Gooren, L.J.G.
DOIAbstract
objective Sex differences are found in most components of the insulin resistance syndrome and the associated cardiovascular risk profile. These differences are attributed to sex-specific sex steroid profiles, but the effects of sex steroids on the individual components of the insulin resistance syndrome remain incompletely understood. design Prospective, intervention study. subjects In 37 young (age range 16¿36 years), nonobese [body mass index (BMI) <29], transsexual subjects, effects of ethinyl oestradiol (100 µg/day) + cyproterone acetate (100 mg/day) administration were evaluated in 20 male-to-female transsexuals and of testosterone-ester administration [250 mg intramuscularly (i.m.)/2 weeks] in 17 female-to-male transsexuals. measureme...
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