Lactic acidosis has different causes, including hypoxia. It is notably treated with dichloroacetate, which stimulates the activity of the pyruvate dehydrogenase enzyme complex in the mitochondrial inner membrane. However, there has been controversy over its efficiency in hypoxic lactic acidosis, particularly in the cerebral tissue and the cerebrospinal fluid. Assess the efficiency of dichloroacetate in the prevention of hypoxia-induced lactic acidosis.We used adult rats, 3 months old, with a weight of 250-300 grams. Anesthesia was achieved by intraperitoneal injection of pentobarbital (Nembutal®), at the dose of 50 mg/kg. For the induction of hypoxia, the rats were given to inspire a gas mixture containing 11% O2 during 45 minutes. There we...
The NTS is one of many sites of chemoreception meaning that it responds to changes in CO2 and pH. NT...
Transient cerebral ischemia (TCI) occurs when blood flow to the brain is ceased or dramatically redu...
The online version of this article, along with updated information and services, is located on th
Lactic acidosis has different causes, including hypoxia. It is notably treated with dichloroacetate,...
SUMMARY Dichloroacetate (DCA) is known to prevent the phosphorylation of the pyrovate dehydroge-nase...
Overwhelming hypoxic acidosis due to poor tissue oxygen delivery from low cardiac output, pulmonary ...
Overwhelming hypoxic acidosis due to poor tissue oxygen delivery from low cardiac output, pulmonary ...
Hypoxic-ischemic (HI) encephalopathy remains a major cause of perinatal mortality and chronic disabi...
Lactate has been shown to offer neuroprotection in several pathologic conditions. This beneficial ef...
Lactate is an intriguing molecule with emerging physiological roles in the brain. It has beneficial ...
The precise mechanism responsible for the increase in plasma lactate concentration during exercise i...
We performed a short-term, double-blind, placebo-controlled, crossover trial of sodium dichloroaceta...
We have studied the effects of lactate on neuronal survival in vitro after oxygen and glucose depriv...
It is well established that lactate can be used as an energy substrate by the brain by conversion to...
INTRODUCTION: Lactic acidosis is a frequent cause of poor outcome in the intensive care settings. We...
The NTS is one of many sites of chemoreception meaning that it responds to changes in CO2 and pH. NT...
Transient cerebral ischemia (TCI) occurs when blood flow to the brain is ceased or dramatically redu...
The online version of this article, along with updated information and services, is located on th
Lactic acidosis has different causes, including hypoxia. It is notably treated with dichloroacetate,...
SUMMARY Dichloroacetate (DCA) is known to prevent the phosphorylation of the pyrovate dehydroge-nase...
Overwhelming hypoxic acidosis due to poor tissue oxygen delivery from low cardiac output, pulmonary ...
Overwhelming hypoxic acidosis due to poor tissue oxygen delivery from low cardiac output, pulmonary ...
Hypoxic-ischemic (HI) encephalopathy remains a major cause of perinatal mortality and chronic disabi...
Lactate has been shown to offer neuroprotection in several pathologic conditions. This beneficial ef...
Lactate is an intriguing molecule with emerging physiological roles in the brain. It has beneficial ...
The precise mechanism responsible for the increase in plasma lactate concentration during exercise i...
We performed a short-term, double-blind, placebo-controlled, crossover trial of sodium dichloroaceta...
We have studied the effects of lactate on neuronal survival in vitro after oxygen and glucose depriv...
It is well established that lactate can be used as an energy substrate by the brain by conversion to...
INTRODUCTION: Lactic acidosis is a frequent cause of poor outcome in the intensive care settings. We...
The NTS is one of many sites of chemoreception meaning that it responds to changes in CO2 and pH. NT...
Transient cerebral ischemia (TCI) occurs when blood flow to the brain is ceased or dramatically redu...
The online version of this article, along with updated information and services, is located on th