Synthesis and Biological Activities of Some Benzimidazoles Derivatives

A set of six novel benzimidazoles compounds were prepared, this includes 5- Nitro-2-phenyl -1-ethylbenzimidazol (5),2-(p-Bromophenyl)-5-nitro-1-ethylbenzimidazol (6), 2- (p- Bromophenyl- 5-nitro-1–cyclopentylbenzimidazol(7),2-(p-Bromophenyl)-5-nitro-1- cyclopentylbenzimidazol (8),5-Amino-2-(p-Bromophenyl)-1-ethylbenzimidazol (9), and 5-Amino- (2- (p- Bromophenyl)- 1- cyclopentylbenzimidazol (10). The chemical structures of these compounds were elucidated using NMR and elemental analysis. The biological activity of these compounds as fungicides was tested against three commercially known fungicides ( Candida albicans , patient isolate Candida glabrata and Candida krusei ).The biological activity of two compounds was found to be comparable to that of the commercially available fungicides (6 and 9)