Outcome of twin ICSI pregnancy compared with spontaneous conceived twin pregnancy: a prospective, controlled, observational study

Objectives: to evaluate the relationship between the type of conception and progress of pregnancy and delivery Settings: Abha Maternity Hospital and the Saudi Center for Assisted Reproduction Design: A prospective cohort study from January, 2004 to January, 2006 Materials and methods: 35 ICSI twin pregnancies and 73 spontaneously conceived twin pregnancies were followed up. The primary outcome was gestational age at delivery, secondary outcome were maternal and neonatal complications and mode of deliveries Results: There was a trend toward preterm labor with ICSI twins than with naturally conceived twins but no significant difference between both groups regarding neonatal weight, Apgar score (A/S) and weight of the placenta. In addition, the post-natal/ neonatal period was similar in both groups. There was no difference in maternal outcomes in both groups. Conclusion(s): When compared to naturally conceived twins, ART-conceived twins are more or less similar to those conceived naturally. A trend towards increased preterm labor should be further investigated in larger studie