The Hedgehog (Hh) signaling pathway plays a critical role in modulating various developmental processes that requires fine tuning of the Hh signal, such that dysregulation can lead to cellular events involved in cancer. To elucidate the factors responsible for aberrant Hh activation and subsequent tumorigenesis, I investigated three distinct modulators of Hh signaling: (1) p53 tumour suppressor (2) primary cilia (3) PTHLH. During chondrocyte development, abnormal Hh signalling can result in benign cartilage tumours, called Enchondroma. As precursor lesions, enchondroma may progress to malignant neoplasia, collectively known as chondrosarcoma. Although the molecular events involved in this progression are poorly understood, inactivation o...
Cholangiocarcinoma (CCA) is a poorly treatable type of cancer and, along with hepatocellular carcino...
[Abstract] The Hedgehog (Hh) family of intercellular signalling proteins have come to be recognised ...
Hedgehog (Hh) signaling regulates cell fate and self-renewal in development and cancer. Canonical Hh...
The Hedgehog (Hh) signaling pathway plays a critical role in modulating various developmental proces...
The Hedgehog (Hh) signalling pathway plays critical roles in both developmental processes and cancer...
Hedgehog (HH) signalling is important for specific developmental processes, and aberrant, increased ...
grantor: University of TorontoEnchondroma is a benign cartilage-forming tumour of bone tha...
The Hedgehog (Hh) pathway is a signaling cascade that plays a crucial role in many fundamental proce...
The Hedgehog (Hh) signaling pathway was first identified in the common fruit fly. It is a highly con...
Despite the combination of chemotherapy and surgery in osteosarcoma treatment, the survival of patie...
Abstract The past decade has seen significant advances in our understanding of Hedgehog (HH) signali...
[Abstract] Hedgehog (Hh) is one of the most important signalling pathways. Together with the Wnt, TG...
The Hedgehog (Hh) signalling pathway is essential for metazoan development and aberrant activation o...
Hedgehog (Hh) signaling is implicated in bone development and cellular transformation. Here we demon...
Hedgehog (Hh) is first described as a genetic mutation that has "spiked" phenotype in the cuticles o...
Cholangiocarcinoma (CCA) is a poorly treatable type of cancer and, along with hepatocellular carcino...
[Abstract] The Hedgehog (Hh) family of intercellular signalling proteins have come to be recognised ...
Hedgehog (Hh) signaling regulates cell fate and self-renewal in development and cancer. Canonical Hh...
The Hedgehog (Hh) signaling pathway plays a critical role in modulating various developmental proces...
The Hedgehog (Hh) signalling pathway plays critical roles in both developmental processes and cancer...
Hedgehog (HH) signalling is important for specific developmental processes, and aberrant, increased ...
grantor: University of TorontoEnchondroma is a benign cartilage-forming tumour of bone tha...
The Hedgehog (Hh) pathway is a signaling cascade that plays a crucial role in many fundamental proce...
The Hedgehog (Hh) signaling pathway was first identified in the common fruit fly. It is a highly con...
Despite the combination of chemotherapy and surgery in osteosarcoma treatment, the survival of patie...
Abstract The past decade has seen significant advances in our understanding of Hedgehog (HH) signali...
[Abstract] Hedgehog (Hh) is one of the most important signalling pathways. Together with the Wnt, TG...
The Hedgehog (Hh) signalling pathway is essential for metazoan development and aberrant activation o...
Hedgehog (Hh) signaling is implicated in bone development and cellular transformation. Here we demon...
Hedgehog (Hh) is first described as a genetic mutation that has "spiked" phenotype in the cuticles o...
Cholangiocarcinoma (CCA) is a poorly treatable type of cancer and, along with hepatocellular carcino...
[Abstract] The Hedgehog (Hh) family of intercellular signalling proteins have come to be recognised ...
Hedgehog (Hh) signaling regulates cell fate and self-renewal in development and cancer. Canonical Hh...