Statins can act as preconditioning agents against ischemia reperfusion (IR)-injury through a mechanism involving cyclooxygenase (COX)-2 and the upregulation of prostaglandin synthesis. The following study investigated the effect of selective and non-selective COX inhibition on rosuvastatin-mediated protection against IR-induced endothelial dysfunction in the human forearm vasculature. Healthy volunteers were randomized to drugs with different COX-inhibiting properties: 81mg aspirin (OD), 325mg aspirin (OD), 400mg ibuprofen (QID), 200mg celecoxib (BID) or placebo. A single dose of 40mg rosuvastatin was also administered 24-hours prior to IR. Endothelial function before and after IR was assessed by measuring flow-mediated dilation of the radi...
BACKGROUND: Acute myocardial infarction is associated with tissue inflammation. Early coronary reper...
Fries S, Grosser T. The cardiovascular pharmacology of COX-2 inhibition. Hematology Am Soc Hematol E...
Item does not contain fulltextStatins are known to have cholesterol-independent pleiotropic effects,...
Statins can act as preconditioning agents against ischemia reperfusion (IR)-injury through a mechani...
ObjectivesThe purpose of this study was to determine whether single-dose rosuvastatin (40 mg) protec...
AbstractObjectivesThe aim of this study was to determine whether selective cyclooxygenase-2 (COX-2) ...
Background: The safe use of selective inhibitors of cyclooxygenase-2 in patients with cardiovascular...
Background—Prostanoid synthesis via the action of cyclooxygenase-2 (COX-2) is a component of the inf...
In this study, we investigated the effects of both 25 and 50 mg daily doses of rofecoxib on the endo...
The development of cyclooxygenase-2 (COX-2) selective inhibitors prompted studies aimed at treating ...
We investigated the effect of atorvastatin on cyclooxygenase (COX) contribution to endothelial dysfu...
The clycoxygenase (COX) enzyme forms locally active prostaglandins responsible for producing inflamm...
Summary: The aim of this study was to assess whether cyclooxygenase (COX) inhibitors protect the end...
AIMS: Cyclooxygenase (COX)-2 expression is increased in inflammation and angiogenesis and also in a...
Selective inhibitors of cyclooxygenase- 2 ( COX- 2, ` coxibs') are highly effective anti-inflammator...
BACKGROUND: Acute myocardial infarction is associated with tissue inflammation. Early coronary reper...
Fries S, Grosser T. The cardiovascular pharmacology of COX-2 inhibition. Hematology Am Soc Hematol E...
Item does not contain fulltextStatins are known to have cholesterol-independent pleiotropic effects,...
Statins can act as preconditioning agents against ischemia reperfusion (IR)-injury through a mechani...
ObjectivesThe purpose of this study was to determine whether single-dose rosuvastatin (40 mg) protec...
AbstractObjectivesThe aim of this study was to determine whether selective cyclooxygenase-2 (COX-2) ...
Background: The safe use of selective inhibitors of cyclooxygenase-2 in patients with cardiovascular...
Background—Prostanoid synthesis via the action of cyclooxygenase-2 (COX-2) is a component of the inf...
In this study, we investigated the effects of both 25 and 50 mg daily doses of rofecoxib on the endo...
The development of cyclooxygenase-2 (COX-2) selective inhibitors prompted studies aimed at treating ...
We investigated the effect of atorvastatin on cyclooxygenase (COX) contribution to endothelial dysfu...
The clycoxygenase (COX) enzyme forms locally active prostaglandins responsible for producing inflamm...
Summary: The aim of this study was to assess whether cyclooxygenase (COX) inhibitors protect the end...
AIMS: Cyclooxygenase (COX)-2 expression is increased in inflammation and angiogenesis and also in a...
Selective inhibitors of cyclooxygenase- 2 ( COX- 2, ` coxibs') are highly effective anti-inflammator...
BACKGROUND: Acute myocardial infarction is associated with tissue inflammation. Early coronary reper...
Fries S, Grosser T. The cardiovascular pharmacology of COX-2 inhibition. Hematology Am Soc Hematol E...
Item does not contain fulltextStatins are known to have cholesterol-independent pleiotropic effects,...