Add to ORKGNeural precursor cells self-renew and differentiate throughout development and in response to neural injury in the adult brain. The DNA damage response in NPCs has yet to be characterized. Patients with defective nucleotide excision repair (NER) demonstrate neurodegeneration dismyelination, and microcephaly, suggesting a potential link to defective NPC function with accumulating DNA damage. We observed reduced self-renewal in Csbm/m and Xpam/m NPCs in response to UV damage. Serial passaging resulted in exhaustion of Csbm/m NPCs in the absence of exogenous DNA damage. In vitro neuronal differentiation resulted in abnormal neuritigenesis after UV DNA damage in Csbm/m NPCs, suggesting defects in the terminal differentiation process. Taken to...
Cockayne syndrome (CS) is a human premature aging disorder associated with neurological and developm...
AbstractA mouse model for the nucleotide excision repair disorder Cockayne syndrome (CS) was generat...
Cockayne syndrome (CS) is a rare premature aging disease, most commonly caused by mutations of the g...
Neural precursor cells self-renew and differentiate throughout development and in response to neural...
Cockayne syndrome (CS) is a progressive developmental and neurodegenerative disorder resulting in pr...
Neuronal degeneration is a hallmark of many DNA repair syndromes. Yet, how DNA damage causes neurona...
Neuronal degeneration is a hallmark of many DNA repair syndromes. Yet, how DNA damage causes neurona...
Cockayne syndrome (CS) is a premature aging condition characterized by sensitivity to UV radiation. ...
Cockayne syndrome (CS) is a congenital syndrome characterized by growth and mental retardation, and ...
Human genetic syndromes deficient in nucleotide excision repair (NER), such as xeroderma pigmentosum...
Hereditary defects in the transcription-coupled nucleotide excision repair (TC-NER) pathway of damag...
Cockayne syndrome (CS) is a human DNA repair-deficient disease that involves transcription coupled r...
Cockayne syndrome (CS) is a rare, autosomal genetic disorder characterized by premature aging-like f...
Hereditary defects in the transcription-coupled nucleotide excision repair (TC-NER) pathway of damag...
The integrity of our genetic material is under constant attack from numerous endogenous and exogenou...
Cockayne syndrome (CS) is a human premature aging disorder associated with neurological and developm...
AbstractA mouse model for the nucleotide excision repair disorder Cockayne syndrome (CS) was generat...
Cockayne syndrome (CS) is a rare premature aging disease, most commonly caused by mutations of the g...
Neural precursor cells self-renew and differentiate throughout development and in response to neural...
Cockayne syndrome (CS) is a progressive developmental and neurodegenerative disorder resulting in pr...
Neuronal degeneration is a hallmark of many DNA repair syndromes. Yet, how DNA damage causes neurona...
Neuronal degeneration is a hallmark of many DNA repair syndromes. Yet, how DNA damage causes neurona...
Cockayne syndrome (CS) is a premature aging condition characterized by sensitivity to UV radiation. ...
Cockayne syndrome (CS) is a congenital syndrome characterized by growth and mental retardation, and ...
Human genetic syndromes deficient in nucleotide excision repair (NER), such as xeroderma pigmentosum...
Hereditary defects in the transcription-coupled nucleotide excision repair (TC-NER) pathway of damag...
Cockayne syndrome (CS) is a human DNA repair-deficient disease that involves transcription coupled r...
Cockayne syndrome (CS) is a rare, autosomal genetic disorder characterized by premature aging-like f...
Hereditary defects in the transcription-coupled nucleotide excision repair (TC-NER) pathway of damag...
The integrity of our genetic material is under constant attack from numerous endogenous and exogenou...
Cockayne syndrome (CS) is a human premature aging disorder associated with neurological and developm...
AbstractA mouse model for the nucleotide excision repair disorder Cockayne syndrome (CS) was generat...
Cockayne syndrome (CS) is a rare premature aging disease, most commonly caused by mutations of the g...