Intrauterine exposures to environmental factors have been hypothesized to influence the risk of breast cancer in adulthood. The majority of epidemiological studies suggest that dietary folate intake is inversely related to breast cancer, however, the evidence have been inconsistent. An animal study was performed to determine the relationship between in utero and postnatal dietary folate intervention and the risk of breast cancer in the DMBA rodent model. Supplementation of maternal and offspring diet with folic acid (5 mg/kg diet) was observed to significantly increase the risk of mammary tumor development in the offspring compared to controls (2 mg/kg diet). Maternal diet and tumor status were also found to be significant predictors of glo...
Increasing evidence supports the developmental origins of adult health and disease hypothesis which ...
Since the late 1990s, the food supply of the United States, Canada, and other countries has been for...
Scope: Epidemiological evidence supports the developmental origins of health and disease hypothesis ...
Intrauterine exposures to environmental factors have been hypothesized to influence the risk of brea...
Epidemiological studies suggest an inverse association between folic acid intake and colorectal canc...
The effects of high maternal folate status on the offspring are unknown; however, early life exposur...
Folic acid (FA) intake has increased over the past decade; however, there are concerns that high lev...
Folic acid supplementation may prevent the development of cancer in normal tissues but may promote t...
Folic acid (FA) intake has been associated with increased breast cancer risk in some studies. Althou...
Folic acid supplementation may prevent the development of cancer in normal tissues but may promote t...
Folate intake in North America has drastically increased over the past decade due to folic acid fort...
SCOPE: Persistent DNA methylation changes may mediate effects of early-life exposures on later-life ...
Background: DNA methylation is programmed during embryogenesis, and folate is critical in the one-ca...
Background: DNA methylation is programmed during embryogenesis, and folate is critical in the one-ca...
Lipotropes (methionine, choline, folate, and vitamin B12) play a key role in one-carbon metabolism. ...
Increasing evidence supports the developmental origins of adult health and disease hypothesis which ...
Since the late 1990s, the food supply of the United States, Canada, and other countries has been for...
Scope: Epidemiological evidence supports the developmental origins of health and disease hypothesis ...
Intrauterine exposures to environmental factors have been hypothesized to influence the risk of brea...
Epidemiological studies suggest an inverse association between folic acid intake and colorectal canc...
The effects of high maternal folate status on the offspring are unknown; however, early life exposur...
Folic acid (FA) intake has increased over the past decade; however, there are concerns that high lev...
Folic acid supplementation may prevent the development of cancer in normal tissues but may promote t...
Folic acid (FA) intake has been associated with increased breast cancer risk in some studies. Althou...
Folic acid supplementation may prevent the development of cancer in normal tissues but may promote t...
Folate intake in North America has drastically increased over the past decade due to folic acid fort...
SCOPE: Persistent DNA methylation changes may mediate effects of early-life exposures on later-life ...
Background: DNA methylation is programmed during embryogenesis, and folate is critical in the one-ca...
Background: DNA methylation is programmed during embryogenesis, and folate is critical in the one-ca...
Lipotropes (methionine, choline, folate, and vitamin B12) play a key role in one-carbon metabolism. ...
Increasing evidence supports the developmental origins of adult health and disease hypothesis which ...
Since the late 1990s, the food supply of the United States, Canada, and other countries has been for...
Scope: Epidemiological evidence supports the developmental origins of health and disease hypothesis ...