Add to ORKGgrantor: University of TorontoIn a significant proportion of LFS families the predisposition to cancer cannot be explained by germline 'p53' mutations. Few other genes have been implicated in this syndrome. The 'PTEN' phosphatase tumor suppressor gene is mutated in human cancers observed in LFS; therefore, it is hypothesized that 'PTEN' may be altered in some ' p53'-wild-type families. LFS primary patient lymphocytes, lymphoblastoid cell cultures and common tumors were examined for 'PTEN' alterations. Germline 'PTEN' mutations were not detected, and a novel intronic deletion found in one LFS-C and one LFS-V individual is predicted to be a polymorphism based on an in vitro mRNA processing assay. 'PTEN' is more frequently deleted in...
Germline mutations in the p53 tumor suppressor gene are associated with the Li-Fraumeni syndrome, ch...
Li-Fraumeni Syndrome (LFS) is a rare cancer syndrome caused by mutations in the TP53 gene. A number ...
Background: Li-Fraumeni (LFS) and Li-Fraumeni-like (LFL) syndromes are associated to germline TP53 m...
grantor: University of TorontoIn a significant proportion of LFS families the predispositi...
Background: Li-Fraumeni syndrome (LFS) is one of the most serious hereditary cancer syndromes with a...
Summary We report a family with the Li-Fraumeni syndrome (LFS) in whom we have been unable to detect...
grantor: University of TorontoThe Li-Fraumeni Syndrome (LFS) is a rare hereditary cancer ...
Pedigree analysis of certain families with a high incidence of tumors suggests a genetic predisposit...
International audienceWe have performed an extensive analysis of TP53 in 474 French families suggest...
Although acquired mutations in the human p53 gene occur in many tumor types, germline mutations are ...
International audienceIn contrast to other tumor suppressor genes, the majority of TP53 alterations ...
Li-Fraumeni syndrome (LFS) is characterized by a variety of neoplasms occurring at a young age with ...
Li-Fraumeni syndrome (LFS) is an autosomal dominantly inherited cancer predisposition syndrome chara...
The PTEN gene is involved in 10q23 deletions in several types of cancer, including glioma, melanoma,...
LiFraumeni syndrome (LFS) is an autosomal dominant cancer predisposition syndrome associated with a ...
Germline mutations in the p53 tumor suppressor gene are associated with the Li-Fraumeni syndrome, ch...
Li-Fraumeni Syndrome (LFS) is a rare cancer syndrome caused by mutations in the TP53 gene. A number ...
Background: Li-Fraumeni (LFS) and Li-Fraumeni-like (LFL) syndromes are associated to germline TP53 m...
grantor: University of TorontoIn a significant proportion of LFS families the predispositi...
Background: Li-Fraumeni syndrome (LFS) is one of the most serious hereditary cancer syndromes with a...
Summary We report a family with the Li-Fraumeni syndrome (LFS) in whom we have been unable to detect...
grantor: University of TorontoThe Li-Fraumeni Syndrome (LFS) is a rare hereditary cancer ...
Pedigree analysis of certain families with a high incidence of tumors suggests a genetic predisposit...
International audienceWe have performed an extensive analysis of TP53 in 474 French families suggest...
Although acquired mutations in the human p53 gene occur in many tumor types, germline mutations are ...
International audienceIn contrast to other tumor suppressor genes, the majority of TP53 alterations ...
Li-Fraumeni syndrome (LFS) is characterized by a variety of neoplasms occurring at a young age with ...
Li-Fraumeni syndrome (LFS) is an autosomal dominantly inherited cancer predisposition syndrome chara...
The PTEN gene is involved in 10q23 deletions in several types of cancer, including glioma, melanoma,...
LiFraumeni syndrome (LFS) is an autosomal dominant cancer predisposition syndrome associated with a ...
Germline mutations in the p53 tumor suppressor gene are associated with the Li-Fraumeni syndrome, ch...
Li-Fraumeni Syndrome (LFS) is a rare cancer syndrome caused by mutations in the TP53 gene. A number ...
Background: Li-Fraumeni (LFS) and Li-Fraumeni-like (LFL) syndromes are associated to germline TP53 m...