ANTI-ULCEROGENIC EFFECTS OF Phyllanthus amarus IN RATS

The effects of aqueous and methanol extracts of Phyllanthus amarus on indomethacin-induced ulceration, gastric acid secretion and on some haematological parameters in male albino rats were studied. The rats for the study of indomethacin-induced ulcerationand haematological parameters were divided into five groups of six rats per group. Aqueous and methanol extracts of Phyllanthus amarus at both high and low doses of 125mg/kg ad 6.25mg/kg respectively were administered orally to the animals for a period of 15days. These doses significantly reduced indomethacin-induced ulceration in the animals (P<0.05). However, the methanolic extract of P. amarus (MePa) appears to be more effective than the aqueous extract of P. amarus. Some haematological parameters namely Packed Cell Volume (PCV), haemoglobin (Hb) concentration, and Red Blood Cell count (RBC) were investigated. While methanolic extract of P. amarus caused significant increase on the investigated haematological parameters, low dose of aqueous extract of P. amarus significant (P