The BOADICEA model of genetic susceptibility to breast and ovarian cancers:Updates and extensions
- Antoniou, A. C.
- Cunningham, A. P.
- Peto, J.
- Evans, D. G.
- Lalloo, F.
- Narod, S. A.
- Risch, H. A.
- Eyfjord, J. E.
- Hopper, J. L.
- Southey, M. C.
- Olsson, H.
- Johannsson, O.
- Borg, A.
- Pasini, B.
- Radice, P.
- Manoukian, S.
- Eccles, D. M.
- Tang, N.
- Olah, E.
- Anton-Culver, H.
- Warner, E.
- Lubinski, J.
- Gronwald, J.
- Gorski, B.
- Tryggvadottir, L.
- Syrjakoski, K.
- Kallioniemi, O. P.
- Eerola, H.
- Nevanlinna, H.
- Pharoah, P. D.P.
- Easton, D. F.
DOIAbstract
Multiple genetic loci confer susceptibility to breast and ovarian cancers. We have previously developed a model (BOADICEA) under which susceptibility to breast cancer is explained by mutations in BRCA1 and BRCA2, as well as by the joint multiplicative effects of many genes (polygenic component). We have now updated BOADICEA using additional family data from two UK population-based studies of breast cancer and family data from BRCA1 and BRCA2 carriers identified by 22 population-based studies of breast or ovarian cancer. The combined data set includes 2785 families (301 BRCA1 positive and 236 BRCA2 positive). Incidences were smoothed using locally weighted regression techniques to avoid large variations between adjacent intervals. A birth co...
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