Pengamatan Visual Tahap-Tahap Pembentukan Kristal Sistem Eutektikum Asetaminofen-Pseudoefedrin Hidroklorida

The aim of this research was to observe the recrystallization process of two component,acetaminophen-pseudoephedrine hydrochloride in ethanol and the thermal profiles.The visual data resulted from polarization microscope observation confirmed withthermograph DSC showed that the crystal habit was represented to the intrinsic characterrepresentative by thermodynamic properties of the binary system.The visualizationprocess proved that in different molar ratios, the binary system formed crystalshabit with different and step by step showed inhibit, to form polycrystalline until atmolar ratio 6:4 formed the fines single crystals mixture which was smaller than beforeco-recrystallization. Acetaminophen was observed as monoclinic hexagonal crystalswhile pseudoephedrine hydrochloride was observed monoclinic/orthorombic forms.Keywords: acetaminophen, crystals habit, ethanol, pseudoephedrine HCl