Intestinal Development and Gene Expression of Piglets Suckling Sows Transgenic for Human Insulin-Like Growth Factor-I

182 p.Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2006.We have shown that piglets suckling IGF exhibit structural and functional changes similar to those observed in piglets receiving formula supplemented with IGF-I. The location and timing of the response to IGF-I differs from previous studies. Insulin like growth factor-I appeared to act via the type I IGF receptor at d 21 in the ileum of piglets suckling IGF. Microarray analysis elucidated differentially expressed genes involved in proliferation, as well as genes involved in immune function and metabolism, suggesting new avenues for IGF-I research.U of I OnlyRestricted to the U of I community idenfinitely during batch ingest of legacy ETD