The Biomedical Applications of Protein Microspheres

Kolbeck, Kenneth J.

Publication date

January 10000

Abstract

303 p.Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1999.Microspheres were produced containing a core of aqueous or organic liquids (i.e., microcapsules) or air (i.e., microbubbles). The microspheres were stabilized by a 60--100 nm protein shell (approximately 10 molecules). The small microsphere diameter (<5 microns) permitted the intravenous injection of microspheres, while the use of native protein in forming the microspheres prevented any significant immune response. We have synthesized microspheres that can be monitored with in vivo imaging techniques (MRI or X-ray) and microscopy. The distribution and circulation lifetime in the bloodstream was extended by modifying the microsphere surface properties. The microspheres w...

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The Biomedical Applications of Protein Microspheres

Abstract

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The Biomedical Applications of Protein Microspheres

Abstract

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