Top Down Mass Spectrometry of Archaea and Human Tumor Cells

133 p.Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2004.A final study was performed applying the top down platform to human HeLa tumor cells. Thirty-four proteins in all were identified, and >90% of these were fully characterized. Several proteins harbored post-translational modifications including N-terminal and internal acetylations, methylations, disulfide bonds, and protein truncations. Proteins were also characterized with known coding single nucleotide polymorphisms, alternative splice variants, and highly homologous gene family members.U of I OnlyRestricted to the U of I community idenfinitely during batch ingest of legacy ETD