Platelet Adhesion and Plasma-Protein Adsorption on Polyacrylonitrile Containing Poly (Ethylene Oxide) Side Chains

Polyacrylonitrile graft copolymers having poly(ethylene oxide) side chains of different number of ethylene oxide unit were synthesized. For the copolymers, adhesion of platelets was examined by a column method, whereby a platelet suspension was passed through a column of glass beads precoated with the copolymer. Independently, adsorption of rat serum albumin (RSA), \gamma\-globulin (R\gamma\G) and fibrinogen (RPF) to the polymer surface was examined in a batch system. Thus, it was found that the degree of the protein adsorption on the polymer surface was in the order of RPF>R\gamma\G>RSA and reduction of the platelet retention for the protein-coated polymer was also in the same order as that of the protein adsorption. From the results, it was concluded that the protein adsorbed on the polymer surface prevents the platelet retention.departmental bulletin pape