Isolation and sequence analysis of a novel rhesus macaque foamyvirus isolate with a serotype?1?like env

AbstractSFVmmu-DPZ9524 represents the third completely sequenced rhesus macaque simian foamy virus (SFV) isolate, alongsideSFVmmu_K3T with a similar SFV-1-type env, and R289HybAGM with a SFV-2-like env. Sequence analysis demonstratesthat, in gag and pol, SFVmmu-DPZ9524 is more closely related to R289HybAGM than to SFVmmu_K3T, which, outsideof env, is more similar to a Japanese macaque isolate than to the other two rhesus macaque isolates SFVmmu-DPZ9524 andR289HybAGM. Further, we identify bel as another recombinant locus in R289HybAGM, confirming that recombinationcontributes to sequence diversity in SFV