Copper(I)-promoted cycloalkylation–peroxidation of unactivated alkenes via sp<sup>3</sup> C–H functionalisation

Banerjee, Arghya
Santra, Sourav Kumar
Mishra, Aniket
Khatun, Nilufa
Patel, Bhisma K.

Open link

Publication date

January 2015

DOI

10.1039/C4OB01962H

Publisher

Royal Society of Chemistry

Abstract

A copper(I)-promoted cycloalkylation–peroxidation strategy has been developed via a three-component reaction involving cycloalkanes, Tert-butyl Hydroperoxide (TBHP) and internal conjugated alkenes possessing Electron-withdrawing Groups (EWGs). This process installs C–O and C–C bonds via sp<sup>3</sup> C–H functionalisation with concomitant generation of two stereocentres. This regioselective radical addition of coumarin system is opposite to that of styrene