Total Synthesis of the Bis-silyl Ether of (+)-15-epi-Aetheramide A

Synthesis of the macrolactone depsipeptide aetheramide A was attempted by three different approaches. The first approach to form the macrolactone involving macrolactonization to form the C1–C21 bond and the second approach using a ring-closing metathesis (RCM) strategy to form the C10–C11 olefinic bond failed. The third approach starting from R-mandelic acid, involving the RCM reaction to install the C18–C19 ring junction, was successful in assembling the macrolactone