Add to ORKGA series of novel homopiperazine derivatives were synthesized and characterized using 1H NMR, LC MS, IR and elemental analysis data. These novel molecules were evaluated for their antiproliferative activity against Reh, leukemia cells using trypan blue and MTT assays. All the molecules showed cytotoxicity with IC50 values between 50-100 μM as calculated by trypan blue assay and greater than 100 μM as calculated by MTT assay. Compound 6b with 3,5-dinitro substituents on phenyl ring of the aryl carboxamide moiety attached to homopiperazine ring showed good activity with IC50 value of 41 μM
International audienceNew N,N'-bis(5-arylidene-4-oxo-4,5-dihydrothiazoline-2-yl)diamine derivatives ...
N,N0-Bis[1-aryl-3-(piperidine-1-yl)propylidene]hydrazine dihydrochlorides were synthesized by the re...
A series of novel 2-(4-(2,4-dimethoxybenzoyl)phenoxy)-1-(4-(3-(piperidin-4-yl)propyl) piperidin-1-yl...
In search of new anticancer agents, a series of novel 1-benzhydryl-4-(substituted phenylcarboxamide/...
Objective: The objective of this study was to synthesize Z- 1-benzhydryl-4-cinnamylpiperazines by no...
In order to explore the antiproliferative effect associated with the piperazine framework, several 1...
A series of novel 1-(4-substitutedbenzoyl)-4-(4-chlorobenzhydryl)piperazine derivatives 5a-g was des...
A series of 3-[(4-substitutedpiperazin-1-yl)methyl]-1H -indole derivatives were synthesized, and the...
The synthesis of a series of substituted hippuric acid (2-benzamidoacetic acid) derivatives containi...
Synthesis and cytotoxic activities of 32 benzhydrylpiperazine derivatives with carboxamide and thioa...
Cataloged from PDF version of article.A series of novel 1-(4-substitutedbenzoyl)-4-(4-chlorobenzhydr...
A series of novel N(3/8)-disubstituted-3,8-diazabicyclo[3.2.1]octanes in order to improve the in vit...
This research was focused on in silico characterization and in vitro biological testing of the serie...
A series of novel arylpiperazine derivatives was synthesized. The in vitro cytotoxic activities of a...
A series of novel 2-(4-(2,4-dimethoxybenzoyl)phenoxy)-1-(4-(3-(piperidin-4-yl)propyl) piperidin-1-yl...
International audienceNew N,N'-bis(5-arylidene-4-oxo-4,5-dihydrothiazoline-2-yl)diamine derivatives ...
N,N0-Bis[1-aryl-3-(piperidine-1-yl)propylidene]hydrazine dihydrochlorides were synthesized by the re...
A series of novel 2-(4-(2,4-dimethoxybenzoyl)phenoxy)-1-(4-(3-(piperidin-4-yl)propyl) piperidin-1-yl...
In search of new anticancer agents, a series of novel 1-benzhydryl-4-(substituted phenylcarboxamide/...
Objective: The objective of this study was to synthesize Z- 1-benzhydryl-4-cinnamylpiperazines by no...
In order to explore the antiproliferative effect associated with the piperazine framework, several 1...
A series of novel 1-(4-substitutedbenzoyl)-4-(4-chlorobenzhydryl)piperazine derivatives 5a-g was des...
A series of 3-[(4-substitutedpiperazin-1-yl)methyl]-1H -indole derivatives were synthesized, and the...
The synthesis of a series of substituted hippuric acid (2-benzamidoacetic acid) derivatives containi...
Synthesis and cytotoxic activities of 32 benzhydrylpiperazine derivatives with carboxamide and thioa...
Cataloged from PDF version of article.A series of novel 1-(4-substitutedbenzoyl)-4-(4-chlorobenzhydr...
A series of novel N(3/8)-disubstituted-3,8-diazabicyclo[3.2.1]octanes in order to improve the in vit...
This research was focused on in silico characterization and in vitro biological testing of the serie...
A series of novel arylpiperazine derivatives was synthesized. The in vitro cytotoxic activities of a...
A series of novel 2-(4-(2,4-dimethoxybenzoyl)phenoxy)-1-(4-(3-(piperidin-4-yl)propyl) piperidin-1-yl...
International audienceNew N,N'-bis(5-arylidene-4-oxo-4,5-dihydrothiazoline-2-yl)diamine derivatives ...
N,N0-Bis[1-aryl-3-(piperidine-1-yl)propylidene]hydrazine dihydrochlorides were synthesized by the re...
A series of novel 2-(4-(2,4-dimethoxybenzoyl)phenoxy)-1-(4-(3-(piperidin-4-yl)propyl) piperidin-1-yl...