More than 85% of c-myc transcription is controlled by the nuclease hypersensitive element III<sub>1</sub> upstream of the P1 promoter of this oncogene. The purine-rich sequence in the anti-sense strand forms a G-quadruplex, which has been recently implicated in colorectal cancer, and is proposed as a silencer element [Proc. Natl. Acad. Sci. USA 101 (2004) 6140]. This prompted us to characterize the thermodynamics and proton/counterion effect of the complementary pyrimidine-rich sequence, which forms a C-tetraplex. We report the thermodynamic parameters for folding of the pyrimidine-rich DNA fragment from this region into a C-tetraplex. At 20°C, we observed a ΔG of −10.36 ± 0.13 kcal mol<sup>−1</sup> with favorable enthalpy (ΔH = −...
The important MYC oncogene is deregulated in many cancer cells and comprises one of the most promine...
Oligodeoxyribonucleotides (ODNs) that are rich in guanines can form four stranded DNA structures kno...
Molekula DNA je kot nosilka genetske informacije predmet številnih raziskav. Poleg dobro znane Watso...
More than 85% of c-myc transcription is controlled by the nuclease hypersensitive element III1 upstr...
The nuclease hypersensitive element NHE IIII is an important anti-cancer target as the transcription...
Abstract Multiple G‐tracts within the promoter region of the c‐myc oncogene may fold into various G...
The role of counterion condensation as a dominant force governing the stability of DNA duplexes and ...
AbstractWe completed a biophysical characterization of the c-MYC proto-oncogene P1 promoter quadrupl...
I-motifs are tetra-helixes that may form in cytosine-rich strands. They are based on cytosine-cytosi...
The human oncogene c-myc is regulated by G-quadruplex formation within the Nuclease Hypersensitive E...
ABSTRACT: DNA sequences with the potential to form secondary structures such as i-motifs (iMs) and G...
dissertationThe intramolecular DNA i-motif is a non-canonical, tetraplex structure that is formed fr...
The development of high fidelity polymerases and streamlined synthesis of threose nucleic acid (TNA)...
G-quadruplex forming sequences are particularly enriched in the promoter regions of eukaryotic genes...
Using isothermal titration calorimetry (ITC), we studied the thermodynamic parameters of the 15-mer ...
The important MYC oncogene is deregulated in many cancer cells and comprises one of the most promine...
Oligodeoxyribonucleotides (ODNs) that are rich in guanines can form four stranded DNA structures kno...
Molekula DNA je kot nosilka genetske informacije predmet številnih raziskav. Poleg dobro znane Watso...
More than 85% of c-myc transcription is controlled by the nuclease hypersensitive element III1 upstr...
The nuclease hypersensitive element NHE IIII is an important anti-cancer target as the transcription...
Abstract Multiple G‐tracts within the promoter region of the c‐myc oncogene may fold into various G...
The role of counterion condensation as a dominant force governing the stability of DNA duplexes and ...
AbstractWe completed a biophysical characterization of the c-MYC proto-oncogene P1 promoter quadrupl...
I-motifs are tetra-helixes that may form in cytosine-rich strands. They are based on cytosine-cytosi...
The human oncogene c-myc is regulated by G-quadruplex formation within the Nuclease Hypersensitive E...
ABSTRACT: DNA sequences with the potential to form secondary structures such as i-motifs (iMs) and G...
dissertationThe intramolecular DNA i-motif is a non-canonical, tetraplex structure that is formed fr...
The development of high fidelity polymerases and streamlined synthesis of threose nucleic acid (TNA)...
G-quadruplex forming sequences are particularly enriched in the promoter regions of eukaryotic genes...
Using isothermal titration calorimetry (ITC), we studied the thermodynamic parameters of the 15-mer ...
The important MYC oncogene is deregulated in many cancer cells and comprises one of the most promine...
Oligodeoxyribonucleotides (ODNs) that are rich in guanines can form four stranded DNA structures kno...
Molekula DNA je kot nosilka genetske informacije predmet številnih raziskav. Poleg dobro znane Watso...