Alterations in the stability of a nucleosome exert predominant influence on chromatin structure and eukaryotic gene expression. In an attempt to investigate the mononucleosome stability using computational approaches, we have simulated the structure of a human mononucleosome and have compared their energies under the influence of core mutations, tail substitutions, variant histones, and orthologs. We observe that mutant nucleosomes carrying SIN (SWI Independent) mutations do not alter the overall nucleosomal structure but cause local structural changes leading to significant changes in energy and hence the stability. We observe that the nucleosome stability is altered by the substitution of only certain critical lysine residues on the H3 ta...
Nucleosomes form the fundamental building blocks of chromatin. Subtle modifications of the constitue...
Nucleosome, a nucleoprotein structure formed by coiling 147bp of DNA around an octamer of histone pr...
ABSTRACT The present study provides in-sights on the dominant mechanisms of motions of the nucleosom...
Previous studies have identified sin mutations that alleviate the requirement for the yeast SWI/SNF ...
The packaging of DNA into nucleosomes impedes the binding and access of molecules involved in its pr...
AbstractHistones are the protein components of the nucleosome, which forms the basic architecture of...
Histone variants play important roles in regulation of chromatin structure and function. To understa...
The H2A.B histone is a highly evolving vertebrate specific variant of the H2A histone family. It has...
The fundamental unit of eukaryotic chromatin is the nucleosome core particle, a protein/DNA complex ...
International audienceAs an important actor in the regulation of nuclear functions, the nucleosomal ...
Background and Aims: Chromatin contains enormous genetic information, with further folding and compa...
Four different histone proteins comprise the octameric histone core, a key component of DNA compacti...
Chromatin organization and composition impart sophisticated regulatory features critical to eukaryot...
AbstractPresented here is a quantitative model of the wrapping and unwrapping of the DNA around the ...
AbstractEvidence is emerging that many diseases result from defects in gene functions, which, in tur...
Nucleosomes form the fundamental building blocks of chromatin. Subtle modifications of the constitue...
Nucleosome, a nucleoprotein structure formed by coiling 147bp of DNA around an octamer of histone pr...
ABSTRACT The present study provides in-sights on the dominant mechanisms of motions of the nucleosom...
Previous studies have identified sin mutations that alleviate the requirement for the yeast SWI/SNF ...
The packaging of DNA into nucleosomes impedes the binding and access of molecules involved in its pr...
AbstractHistones are the protein components of the nucleosome, which forms the basic architecture of...
Histone variants play important roles in regulation of chromatin structure and function. To understa...
The H2A.B histone is a highly evolving vertebrate specific variant of the H2A histone family. It has...
The fundamental unit of eukaryotic chromatin is the nucleosome core particle, a protein/DNA complex ...
International audienceAs an important actor in the regulation of nuclear functions, the nucleosomal ...
Background and Aims: Chromatin contains enormous genetic information, with further folding and compa...
Four different histone proteins comprise the octameric histone core, a key component of DNA compacti...
Chromatin organization and composition impart sophisticated regulatory features critical to eukaryot...
AbstractPresented here is a quantitative model of the wrapping and unwrapping of the DNA around the ...
AbstractEvidence is emerging that many diseases result from defects in gene functions, which, in tur...
Nucleosomes form the fundamental building blocks of chromatin. Subtle modifications of the constitue...
Nucleosome, a nucleoprotein structure formed by coiling 147bp of DNA around an octamer of histone pr...
ABSTRACT The present study provides in-sights on the dominant mechanisms of motions of the nucleosom...