Add to ORKGThe cloning and deduced amino acid sequence of Plasmodium falciparum adenylosuccinate synthetase (PfADSS) are reported. PfADSS exhibited 67% homology with the human enzyme. On expression in Escherichia coli, enzymatically active ADSS was produced as deduced by functional complementation analysis. The PfADSS activity was inhibited by hadacidin, a known competitive inhibitor of this enzyme. Nucleotide sequence data are available at GenBank under accession number AF095282
AbstractA series of 10 1,4-bis(3-aminopropyl)piperazine compounds was found to display antiplasmodia...
Mutations in Plasmodium falciparum dihydropteroate synthase have been linked to resistance to the an...
Background: Plasmodium vivax is the most widespread human malaria parasite. However, genetic informa...
In the absence of the de novo purine nucleotide biosynthetic pathway in parasitic protozoa, purine s...
In the absence of the de novo purine nucleotide biosynthetic pathway in parasitic protozoa, purine s...
Most parasitic protozoa lack the de novo purine biosynthetic pathway and rely exclusively on the sal...
Adenylosuccinate synthetase catalyzes a reversible reaction utilizing IMP, GTP and aspartate in the ...
S-Adenosylmethionine (AdoMet) synthetase (SAMS:EC2.5.1.6) catalyses the formation of AdoMet from met...
Adenylosuccinate synthetase (AdSS) catalyses the Mg<SUP>2+</SUP> dependent formation of adenylosucci...
Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (DHFR-TS) is a well-known target ...
The emergence of drug-resistant forms of Plasmodium falciparum emphasizes the need to develop new an...
The human malaria parasite Plasmodium falciparum synthesizes fatty acids by using a type II synthase...
Recombinant S-adenosyl-L-homocysteine (SAH) hydrolase of the malaria parasite Plas-modium falciparum...
Untersucht wurde die an eine N-terminale Ionenkanaldomäne gekoppelte singuläre Adenylatcyclase (AC) ...
The emergence of drug-resistant forms of Plasmodium falciparum emphasizes the need to develop new an...
AbstractA series of 10 1,4-bis(3-aminopropyl)piperazine compounds was found to display antiplasmodia...
Mutations in Plasmodium falciparum dihydropteroate synthase have been linked to resistance to the an...
Background: Plasmodium vivax is the most widespread human malaria parasite. However, genetic informa...
In the absence of the de novo purine nucleotide biosynthetic pathway in parasitic protozoa, purine s...
In the absence of the de novo purine nucleotide biosynthetic pathway in parasitic protozoa, purine s...
Most parasitic protozoa lack the de novo purine biosynthetic pathway and rely exclusively on the sal...
Adenylosuccinate synthetase catalyzes a reversible reaction utilizing IMP, GTP and aspartate in the ...
S-Adenosylmethionine (AdoMet) synthetase (SAMS:EC2.5.1.6) catalyses the formation of AdoMet from met...
Adenylosuccinate synthetase (AdSS) catalyses the Mg<SUP>2+</SUP> dependent formation of adenylosucci...
Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (DHFR-TS) is a well-known target ...
The emergence of drug-resistant forms of Plasmodium falciparum emphasizes the need to develop new an...
The human malaria parasite Plasmodium falciparum synthesizes fatty acids by using a type II synthase...
Recombinant S-adenosyl-L-homocysteine (SAH) hydrolase of the malaria parasite Plas-modium falciparum...
Untersucht wurde die an eine N-terminale Ionenkanaldomäne gekoppelte singuläre Adenylatcyclase (AC) ...
The emergence of drug-resistant forms of Plasmodium falciparum emphasizes the need to develop new an...
AbstractA series of 10 1,4-bis(3-aminopropyl)piperazine compounds was found to display antiplasmodia...
Mutations in Plasmodium falciparum dihydropteroate synthase have been linked to resistance to the an...
Background: Plasmodium vivax is the most widespread human malaria parasite. However, genetic informa...