Add to ORKGl-Aryl-4-oxo-4,5,6,7-tetrahydroindoles (1-16) have been synthesised by the condensation of cyclohexane-l,3-dione-2-acetic esters with anilines. Hydrolysis of 1-16 affords the corresponding acids( 17-32), bearing resemblance to the nonsteroidal antiinflammatory agent, diclofenac 38. Some members of both classes show antiinflammatory activity in the carragenin oedema test and analgesic activity in mouse writhing test, but are devoid of prostaglandin synthetase inhibiting property. Among these, 1-carboxymethylene-2-(4-trifluoromeihylanilino)-l-cyclohexen-6-one (20) has marginal activity in the chronic adjuvant arthritis model of inflammation
The green chemistry approach provides for the synthesis of coumarin-1,4-dihydropyridine scaffolds 6a...
An enantioselective and diastereoselective approach toward the synthesis of the polycyclic norditerp...
5HT1A receptor targeting drugs have been used as the treatment for the many neuropsychiatric disord...
A series of N-Aroyl-cyclohexyl- and cyclohexenylamides 3- or 4-methylsubstituted were synthesized an...
In continuation of our search for new substituted pyridine based anti-inflammatories, reaction of 1-...
AbstractAminoacetylenic isoindoline-1,3-dione derivatives were synthesized from the reaction of pota...
Following our previous research on anti-inflammatory drugs (NSAIDs), we report here the synthesis of...
There is a constant search for analgesic drugs to control the pain while promoting as few side effec...
There is increasing evidence that prostaglandins are mediators of inflammation in skin and that pros...
AbstractA series of novel ethyl-5-amino-3-methylthio-1H-pyrazole-4-carboxylates 3a–j were synthesize...
AbstractThe title compounds 3a–l have been synthesized by the reaction of thiocarbohydrazide with su...
Supplementary material for: [https://doi.org/10.1016/j.bmc.2015.05.052]Related to published version:...
This study was designed to determine the fate of the nonsteroid antiandrogen flutamide in men follow...
AbstractPreviously, we have demonstrated the analgesic-like property of p-cymene in rodents. Short h...
The synthesis of an isosteric-isoelectronic analogue of prekinamycin, an N-cyanobenzo[b]carbazoloqui...
The green chemistry approach provides for the synthesis of coumarin-1,4-dihydropyridine scaffolds 6a...
An enantioselective and diastereoselective approach toward the synthesis of the polycyclic norditerp...
5HT1A receptor targeting drugs have been used as the treatment for the many neuropsychiatric disord...
A series of N-Aroyl-cyclohexyl- and cyclohexenylamides 3- or 4-methylsubstituted were synthesized an...
In continuation of our search for new substituted pyridine based anti-inflammatories, reaction of 1-...
AbstractAminoacetylenic isoindoline-1,3-dione derivatives were synthesized from the reaction of pota...
Following our previous research on anti-inflammatory drugs (NSAIDs), we report here the synthesis of...
There is a constant search for analgesic drugs to control the pain while promoting as few side effec...
There is increasing evidence that prostaglandins are mediators of inflammation in skin and that pros...
AbstractA series of novel ethyl-5-amino-3-methylthio-1H-pyrazole-4-carboxylates 3a–j were synthesize...
AbstractThe title compounds 3a–l have been synthesized by the reaction of thiocarbohydrazide with su...
Supplementary material for: [https://doi.org/10.1016/j.bmc.2015.05.052]Related to published version:...
This study was designed to determine the fate of the nonsteroid antiandrogen flutamide in men follow...
AbstractPreviously, we have demonstrated the analgesic-like property of p-cymene in rodents. Short h...
The synthesis of an isosteric-isoelectronic analogue of prekinamycin, an N-cyanobenzo[b]carbazoloqui...
The green chemistry approach provides for the synthesis of coumarin-1,4-dihydropyridine scaffolds 6a...
An enantioselective and diastereoselective approach toward the synthesis of the polycyclic norditerp...
5HT1A receptor targeting drugs have been used as the treatment for the many neuropsychiatric disord...