Initiation of menstrual cyclicity and deciduomal reaction in the Bonnet monkey (Macaca radiata)

Decidualization has been induced in immature and acyclic mature bonnet monkeys by following a 30-day estrogen-progesterone combined therapy, traumatization being achieved on day 16 of treatment. This treatment led to an increase in the weight and glycogen content of the uterus. Histological examination of the uterus of traumatized animals revealed typical decidual cell pockets resembling a plaque reaction. Regular menstrual cyclicity has been induced in bonnet monkeys, which tend to show an amenorrheic behaviour soon after capture and transfer to the laboratory, by following a combination of estrogen and progresterone therapy