Wegener's granulomatosis (WG) and polyarteritis nodosa (PAN) are systemic necrotizing vasculitides of unknown etiology. These disorders run a fatal course if untreated. T lymphocytes are implicated in the pathogenesis of WG, since they have been found to infiltrate affected organs, and sIL-2R correlates with disease activity. To elucidate further the role of T cells in necrotizing vasculitis, we have used a panel of 12 TCR V-specific MoAbs to investigate the number of cells expressing certain V alpha and V beta gene segments in the CD4+ and CD8+ subsets of altogether 11 patients with WG or PAN. In the group of patients, we found abnormal expansions of T cells using particular TCR V alpha or V beta gene products. These T cell expansions were...
A patient with large granular lymphocyte (LGL) expansion (T-gamma lymphocytosis), neutropenia and th...
In order to test the hypothesis that Wegener's granulomatosis (WG) is associated with an ongoing imm...
We studied T-cell receptor (TCR) repertoire of circulating gamma delta ( γδ) T-cells in 20...
T lymphocytes are implicated in the pathogenesis of systemic vasculitis such as Wegener's granulomat...
T lymphocytes are of critical importance for initiating and controlling immune responses, as the T c...
In Wegener's granulomatosis (WG), a form of autoimmune systemic vasculitis, chronic carriage of Stap...
Polymerase chain reaction (PCR) technology was employed to examine peripheral blood and synovial T c...
Objectives: Wegener's granulomatosis (WG) is a chronic inflammatory disease characterized by granulo...
Behcet's disease (BD) is a chronic multisystemic inflammatory disorder characterized mainly by recur...
Although the cause of ANCA-associated vasculitis (AAV) remains undetermined, the presence of lymphoc...
Takayasu's arteritis (TA) is a chronic large vessel vasculitis with a predilection for the aortic ar...
Human atheromata contain T lymphocytes, but knowledge of the function and receptor specificity of th...
T Iymphocytes use the T cell receptor (TCR) to specifically recognize antigens. According to the typ...
In order to test the hypothesis that Wegener's granulomatosis (WG) is associated with an ongoing imm...
T lymphocytes use the T cell receptor (TCR) to specifically recognize antigens. According to the typ...
A patient with large granular lymphocyte (LGL) expansion (T-gamma lymphocytosis), neutropenia and th...
In order to test the hypothesis that Wegener's granulomatosis (WG) is associated with an ongoing imm...
We studied T-cell receptor (TCR) repertoire of circulating gamma delta ( γδ) T-cells in 20...
T lymphocytes are implicated in the pathogenesis of systemic vasculitis such as Wegener's granulomat...
T lymphocytes are of critical importance for initiating and controlling immune responses, as the T c...
In Wegener's granulomatosis (WG), a form of autoimmune systemic vasculitis, chronic carriage of Stap...
Polymerase chain reaction (PCR) technology was employed to examine peripheral blood and synovial T c...
Objectives: Wegener's granulomatosis (WG) is a chronic inflammatory disease characterized by granulo...
Behcet's disease (BD) is a chronic multisystemic inflammatory disorder characterized mainly by recur...
Although the cause of ANCA-associated vasculitis (AAV) remains undetermined, the presence of lymphoc...
Takayasu's arteritis (TA) is a chronic large vessel vasculitis with a predilection for the aortic ar...
Human atheromata contain T lymphocytes, but knowledge of the function and receptor specificity of th...
T Iymphocytes use the T cell receptor (TCR) to specifically recognize antigens. According to the typ...
In order to test the hypothesis that Wegener's granulomatosis (WG) is associated with an ongoing imm...
T lymphocytes use the T cell receptor (TCR) to specifically recognize antigens. According to the typ...
A patient with large granular lymphocyte (LGL) expansion (T-gamma lymphocytosis), neutropenia and th...
In order to test the hypothesis that Wegener's granulomatosis (WG) is associated with an ongoing imm...
We studied T-cell receptor (TCR) repertoire of circulating gamma delta ( γδ) T-cells in 20...