The hepatitis B virus (HBV) DNA contains an open reading frame (ORF) designated X, which has the capacity to encode a protein of 16,560 Da (subtype adw). Such a protein has not been identified in either HBV particles or infected human livers, and therefore its role in the viral life cycle remains unknown. We report here the expression of the HBV X ORF in cultured cells using recombinant vectors. A protein of 16 kDa was identified by means of an antiserum prepared against a synthetic peptide and with human antisera from hepatitis B patients as well as those with hepatocellular carcinoma. Cell fractionation and immunofluorescence studies suggest a probable association with cytoskeletal components. Our studies further located a promoter sequen...
Chronic infection of the hepatitis B virus (HBV) is one of the causes leading to liver cancer. The 3...
The construction of the first stable human cell lines that express and secrete authentic hepatitis B...
AIM: To investigate the possible mechanism for HBV X gene to induce apoptosis of hepatocyte HL-7702 ...
All mammalian hepatitis B virus genomes contain an open reading frame X (X-ORF) of unknown function ...
We prepared human hepatoma cell lines, which expressed the human hepatitis B virus-X gene product. T...
The hepatitis B x (HBx) gene is the smallest open reading frame of the hepatitis B virus (HBV) genom...
BackgroundThe hepatitis B virus (HBV) pre-X gene resides upstream of the HBV X gene, and together th...
AbstractSubcellular localization and transactivation of human hepatitis B virus X protein (HBx), a p...
Background & Aims: The molecular biology of hepatitis B virus (HBV) has been extensively studied but...
BACKGROUND & AIMS:The molecular biology of hepatitis B virus (HBV) has been extensively studied ...
Hepatitis B viral (HBV) infection is the commonest cause of hepatocellular carcinoma. HBV DNA is the...
The hepatitis B virus (HBV) genome is made of a small partially double-stranded, circular DNA that e...
The hepatitis B virus (HBV)-encoded X antigen (HBxAg) may contribute to the development of hepatocel...
Hepatitis B virus X (HBx) protein is a multifunctional protein that exerts dual activity on cell pro...
Chronic hepatitis B virus (HBV) infection is a major risk factor for liver cancer development. HBV e...
Chronic infection of the hepatitis B virus (HBV) is one of the causes leading to liver cancer. The 3...
The construction of the first stable human cell lines that express and secrete authentic hepatitis B...
AIM: To investigate the possible mechanism for HBV X gene to induce apoptosis of hepatocyte HL-7702 ...
All mammalian hepatitis B virus genomes contain an open reading frame X (X-ORF) of unknown function ...
We prepared human hepatoma cell lines, which expressed the human hepatitis B virus-X gene product. T...
The hepatitis B x (HBx) gene is the smallest open reading frame of the hepatitis B virus (HBV) genom...
BackgroundThe hepatitis B virus (HBV) pre-X gene resides upstream of the HBV X gene, and together th...
AbstractSubcellular localization and transactivation of human hepatitis B virus X protein (HBx), a p...
Background & Aims: The molecular biology of hepatitis B virus (HBV) has been extensively studied but...
BACKGROUND & AIMS:The molecular biology of hepatitis B virus (HBV) has been extensively studied ...
Hepatitis B viral (HBV) infection is the commonest cause of hepatocellular carcinoma. HBV DNA is the...
The hepatitis B virus (HBV) genome is made of a small partially double-stranded, circular DNA that e...
The hepatitis B virus (HBV)-encoded X antigen (HBxAg) may contribute to the development of hepatocel...
Hepatitis B virus X (HBx) protein is a multifunctional protein that exerts dual activity on cell pro...
Chronic hepatitis B virus (HBV) infection is a major risk factor for liver cancer development. HBV e...
Chronic infection of the hepatitis B virus (HBV) is one of the causes leading to liver cancer. The 3...
The construction of the first stable human cell lines that express and secrete authentic hepatitis B...
AIM: To investigate the possible mechanism for HBV X gene to induce apoptosis of hepatocyte HL-7702 ...