Purpose: Although complex idiopathic generalized epilepsies (IGEs) are recognized to have a significant genetic component, as yet there are no known common susceptibility variants. It has recently been suggested that variation in the BRD2 gene confers increased risk of juvenile myoclonic epilepsy (JME), which accounts for around a quarter of all IGE. Here we examine the association between the candidate causal SNP (the promoter variant rs3918149) and JME in five independent cohorts comprising in total 531 JME cases and 1,390 healthy controls. Methods: The strongest candidate causal variant from the original report (rs3918149) was genotyped across all five cohorts. In an effort to identify novel candidate causal polymorphisms, previously uns...
Hereditary factors play a major role in the genetically complex etiology of juvenile myoclonic epile...
Juvenile myoclonic epilepsy (JME) is a genetically determined common subtype of idiopathic generaliz...
peer reviewedWith regard to the article by Bailey et al. (March 15, 2018, issue) on the potential ro...
The definitive version is available at www.blackwell-synergy.comPurposeAlthough complex idiopathic g...
Juvenile myoclonic epilepsy (JME) is a common form of generalized epilepsy that starts in adolescenc...
This article outlines recent findings on genetics of juvenile myoclonic epilepsy (JME), where JME oc...
BackgroundSeveral genetic association investigations have been performed over the last three decades...
In recent years, the genetics of juvenile myoclonic epilepsy (JME) has been actively studied; the as...
Juvenile myoclonic epilepsy (JME) is a common syndrome of genetic generalized epilepsies (GGEs). Lin...
Juvenile myoclonic epilepsy (JME) is a common syndrome of genetic generalized epilepsies (GGEs). Lin...
Juvenile myoclonic epilepsy (JME) is a common syndrome of genetic generalized epilepsies (GGEs). Lin...
Juvenile myoclonic epilepsy (JME) is a genetically determined common subtype of idiopathic generaliz...
The epilepsies are a group of disorders characterised by recurrent seizures caused by episodes of ab...
A trait locus for electroencephalographic photoparoxysmal response (PPR) has been mapped to the chro...
SummaryEvidence for genetic influences in epilepsy is strong, but reports identifying specific chrom...
Hereditary factors play a major role in the genetically complex etiology of juvenile myoclonic epile...
Juvenile myoclonic epilepsy (JME) is a genetically determined common subtype of idiopathic generaliz...
peer reviewedWith regard to the article by Bailey et al. (March 15, 2018, issue) on the potential ro...
The definitive version is available at www.blackwell-synergy.comPurposeAlthough complex idiopathic g...
Juvenile myoclonic epilepsy (JME) is a common form of generalized epilepsy that starts in adolescenc...
This article outlines recent findings on genetics of juvenile myoclonic epilepsy (JME), where JME oc...
BackgroundSeveral genetic association investigations have been performed over the last three decades...
In recent years, the genetics of juvenile myoclonic epilepsy (JME) has been actively studied; the as...
Juvenile myoclonic epilepsy (JME) is a common syndrome of genetic generalized epilepsies (GGEs). Lin...
Juvenile myoclonic epilepsy (JME) is a common syndrome of genetic generalized epilepsies (GGEs). Lin...
Juvenile myoclonic epilepsy (JME) is a common syndrome of genetic generalized epilepsies (GGEs). Lin...
Juvenile myoclonic epilepsy (JME) is a genetically determined common subtype of idiopathic generaliz...
The epilepsies are a group of disorders characterised by recurrent seizures caused by episodes of ab...
A trait locus for electroencephalographic photoparoxysmal response (PPR) has been mapped to the chro...
SummaryEvidence for genetic influences in epilepsy is strong, but reports identifying specific chrom...
Hereditary factors play a major role in the genetically complex etiology of juvenile myoclonic epile...
Juvenile myoclonic epilepsy (JME) is a genetically determined common subtype of idiopathic generaliz...
peer reviewedWith regard to the article by Bailey et al. (March 15, 2018, issue) on the potential ro...