Stereoselective syntheses of (−)-tetrahydrolipstatin via Prins cyclisations

Stereoselective syntheses of (−)-tetrahydrolipstatin have been achieved via two divergent approaches through Prins cyclisations as the key steps. PCC mediated oxidative cleavage, Frater alkylation, Keck allylation, Sharpless asymmetric epoxidation and allylic cleavage were the other key steps employed