The metabolic differences between the muscle biopsies of patients with limb girdle muscular dystrophy (LGMD) and normal controls were characterized using high-resolution 1H and 13C NMR spectroscopy. In all, 44 metabolites were unambiguously assigned in the perchloric acid extracts of skeletal muscle tissue, using 2D double quantum filtered (DQF COSY), total correlation (TOCSY), and 1H/13C heteronuclear multiple quantum coherence (HMQC) spectroscopy. The concentrations of glycolytic substrate, glucose (p=0.03), gluconeogenic amino acids, glutamine (p=0.02) and alanine (p=0.009) together with glycolytic product, lactate (p=0.04), were found to be significantly lowered in LGMD patients as compared with controls. The reduction in the concentrat...
Nuclear Magnetic Resonance is one of the few non-invasive techniques for metabolic investigation. It...
New developments in in vivo 2D 1H NMR spectroscopy now allow several metabolites, which are not reso...
Magnetic resonance spectroscopy (MRS) of skeletal muscle has been successfully applied by physiologi...
The metabolic differences between the muscle biopsies of patients with limb girdle muscular dystroph...
The metabolic differences in the skeletal muscle of patients with Duchenne muscular dystrophy (DMD) ...
Duchenne muscular dystrophy (DMD) is a recessive X-linked form of muscular dystrophy characterized b...
Proton magnetic resonance spectroscopy was used in vivo to evaluate muscle metabolism in patients wi...
A principal problem in understanding the functional genomics of a pathology is the wide-reaching bio...
International audienceAbstract Duchenne muscular dystrophy (DMD) is a common and severe X-linked myo...
Recent years have seen tremendous progress towards therapy of many previously incurable neuromuscula...
Magnetic resonance spectroscopy (MRS) and spectroscopic imaging (MRSI) provide metabolic information...
International audienceQuantitative NMRI and (31) P NMRS indices are reported in the forearms of 24 p...
Facioscapulohumeral muscular dystrophy (FSHD) is a hereditary neuromuscular disorder characterized b...
Carbon-13 magnetic resonance spectroscopy (13C MRS) offers a noninvasive method to assess glycogen l...
Two peaks consistently arise near 1.3 ppm in $\sp1$H NMR spectroscopic studies of fatiguing skeletal...
Nuclear Magnetic Resonance is one of the few non-invasive techniques for metabolic investigation. It...
New developments in in vivo 2D 1H NMR spectroscopy now allow several metabolites, which are not reso...
Magnetic resonance spectroscopy (MRS) of skeletal muscle has been successfully applied by physiologi...
The metabolic differences between the muscle biopsies of patients with limb girdle muscular dystroph...
The metabolic differences in the skeletal muscle of patients with Duchenne muscular dystrophy (DMD) ...
Duchenne muscular dystrophy (DMD) is a recessive X-linked form of muscular dystrophy characterized b...
Proton magnetic resonance spectroscopy was used in vivo to evaluate muscle metabolism in patients wi...
A principal problem in understanding the functional genomics of a pathology is the wide-reaching bio...
International audienceAbstract Duchenne muscular dystrophy (DMD) is a common and severe X-linked myo...
Recent years have seen tremendous progress towards therapy of many previously incurable neuromuscula...
Magnetic resonance spectroscopy (MRS) and spectroscopic imaging (MRSI) provide metabolic information...
International audienceQuantitative NMRI and (31) P NMRS indices are reported in the forearms of 24 p...
Facioscapulohumeral muscular dystrophy (FSHD) is a hereditary neuromuscular disorder characterized b...
Carbon-13 magnetic resonance spectroscopy (13C MRS) offers a noninvasive method to assess glycogen l...
Two peaks consistently arise near 1.3 ppm in $\sp1$H NMR spectroscopic studies of fatiguing skeletal...
Nuclear Magnetic Resonance is one of the few non-invasive techniques for metabolic investigation. It...
New developments in in vivo 2D 1H NMR spectroscopy now allow several metabolites, which are not reso...
Magnetic resonance spectroscopy (MRS) of skeletal muscle has been successfully applied by physiologi...