The responses in vitro of cartilage to somatomedin and of thymocytes to growth hormone have been studied in tissues derived from rats of various ages. The basal and somatomedin stimulated incorporation of radioactive proline into proteins and of sulphate into mucopolysaccharides diminishes markedly with age. Chondrocytes per unit area in cartilage of old rats are about 4- to 5-fold reduced in number as compared to those in cartilage from 1-day old rats. The organ size and yield of thymocytes are reduced in aged rats. Besides the fall in number of cells, the average metabolic activity of cells as measured by uridine incorporation into RNA in vitro is also diminished. There is a progressive decline in stimulation by growth hormone of uridine ...
Growth hormone (GH) declines during aging. This study investigates whether pituitary constitutive al...
In old mammals, including humans, the spontaneous growth hormone (GH) secretory pattern is markedly ...
The various cell types in mouse thymus have been defined histologicsily and quantitative com-parison...
The responses in vitro of cartilage to somatomedin and of thymocytes to growth hormone have been stu...
In order to provide a morphometrical description of the changes in the aged rat thymus and to relate...
The electrophoretic mobility and surface charge of thymocytes was reduced on incubation of the cells...
Animals and humans become increasingly susceptible to infectious, arthritic, and neoplastic diseases...
Regulation of T lymphocyte proliferation from aged rats was explored by activating lymphocytes to pr...
In aged animals and humans the pulsatile secretion of growth hormone (GH), the mean amounts of GH re...
Surgical removal of the pituitary (hypophysectomy) followed by endocrine supplementation in middle-a...
The purpose of the present study is to determine whether or not the differences in cellular prolifer...
Four- and 21-month old female Sprague-Dawley rats were sacrificed and their tibiae and femurs isolat...
Structural and phenotypic modifications of rat thymocytes from birth up to one year of age, i.e. dur...
The study was undertaken to assess the effects of ovarian hormone withdrawal in prepubertal age on t...
The role of the glucocorticoid receptor (GR) in senescence was studied in rats of increasing age. St...
Growth hormone (GH) declines during aging. This study investigates whether pituitary constitutive al...
In old mammals, including humans, the spontaneous growth hormone (GH) secretory pattern is markedly ...
The various cell types in mouse thymus have been defined histologicsily and quantitative com-parison...
The responses in vitro of cartilage to somatomedin and of thymocytes to growth hormone have been stu...
In order to provide a morphometrical description of the changes in the aged rat thymus and to relate...
The electrophoretic mobility and surface charge of thymocytes was reduced on incubation of the cells...
Animals and humans become increasingly susceptible to infectious, arthritic, and neoplastic diseases...
Regulation of T lymphocyte proliferation from aged rats was explored by activating lymphocytes to pr...
In aged animals and humans the pulsatile secretion of growth hormone (GH), the mean amounts of GH re...
Surgical removal of the pituitary (hypophysectomy) followed by endocrine supplementation in middle-a...
The purpose of the present study is to determine whether or not the differences in cellular prolifer...
Four- and 21-month old female Sprague-Dawley rats were sacrificed and their tibiae and femurs isolat...
Structural and phenotypic modifications of rat thymocytes from birth up to one year of age, i.e. dur...
The study was undertaken to assess the effects of ovarian hormone withdrawal in prepubertal age on t...
The role of the glucocorticoid receptor (GR) in senescence was studied in rats of increasing age. St...
Growth hormone (GH) declines during aging. This study investigates whether pituitary constitutive al...
In old mammals, including humans, the spontaneous growth hormone (GH) secretory pattern is markedly ...
The various cell types in mouse thymus have been defined histologicsily and quantitative com-parison...