Mechanism of action of estrogens

The discussion centers mainly on the mode of action of estradiol, though relevant issues are evoked for other steroid hormones. The problem is examined from the following angles: 1. 1. Initial interaction of estradiol with the target tissues; the isolation, properties, and characteristics of the "receptor" fraction from the uterus; and a possible molecular basis for the biological response of selected organs to this hormone are discussed. 2. 2. The relative importance of the synthesis of RNA and proteins in the development of the "total organ response" to this hormone is evaluated in light of the available data. 3. 3. The successes and failures of obtaining the hormone action in an in vitro system are discussed. 4. 4. The current status of our knowledge (and ignorance) of the mode of action of estradiol is summarized