AA·TT and GA·TC dinucleotide steps in B-DNA-type oligomeric crystal structures and in protein-bound DNA fragments (solved using data with resolution <2.6 Å) show very small variations in their local dinucleotide geometries. A detailed analysis of these crystal structures reveals that in AA·TT and GA·TC steps the electropositive C2-H2 group of adenine is in very close proximity to the keto O atoms of both the pyrimidine bases in the antiparallel strand of the duplex structure, suggesting the possibility of intra-base pair as well as cross-strand inter-base pair C-HO hydrogen bonds in the DNA minor groove. The C2-H2O2 hydrogen bonds in the A·T base pairs could be a natural consequence of Watson-Crick pairing. ...
BACKGROUND: The flexibility of DNA enables it to adopt three interconvertible types of duplex termed...
Hydroxyl radicals are potent mutagens that attack DNA to form various base and ribose derivatives. O...
An analysis of the base pair doublet geometries in available crystal structures indicates that the o...
$AA^.TT$ and $GA^.TC$ dinucleotide steps in B-DNA-type oligomeric crystal structures and in protein-...
Analysis of available B-DNA type oligomeric crystal structures as well as protein-bound DNA fragment...
Analysis of available β-DNA type oligomeric crystal structures as well as protein-bound DNA fragment...
Minor groove hydrogen bonding (HB) interactions between DNA polymerases (pols) and N3 of purines or ...
The geometry of the hydrogen bonding interaction between DNA and minor-groove binding drugs has been...
International audiencethe crystal packing of the B-DNA dodecamer d(ACCG-GCGCCACA).d(TGTGGCGCCGGT) is...
The role of microhydration in structural adjustments of the AT-tract in B-DNA was studied at the B97...
The synthetic deoxydodecamer d(C-G-C-G-A-A-T-T-A-G-C-G) was analyzed by x-ray diffraction methods, a...
The structure of the deoxyoligomer d(C-G-C-G-A-A-T-T-T-G-C-G) was determined at 2.5-A resolution by ...
The results of the search for low-energy conformations of poly(dA). poly(dT) and of the poly(dA).pol...
The physical configuration of double-stranded DNA plays a significant role in the protection and exp...
An analysis of the base pair doublet geometries in available crystal structures indicates that the o...
BACKGROUND: The flexibility of DNA enables it to adopt three interconvertible types of duplex termed...
Hydroxyl radicals are potent mutagens that attack DNA to form various base and ribose derivatives. O...
An analysis of the base pair doublet geometries in available crystal structures indicates that the o...
$AA^.TT$ and $GA^.TC$ dinucleotide steps in B-DNA-type oligomeric crystal structures and in protein-...
Analysis of available B-DNA type oligomeric crystal structures as well as protein-bound DNA fragment...
Analysis of available β-DNA type oligomeric crystal structures as well as protein-bound DNA fragment...
Minor groove hydrogen bonding (HB) interactions between DNA polymerases (pols) and N3 of purines or ...
The geometry of the hydrogen bonding interaction between DNA and minor-groove binding drugs has been...
International audiencethe crystal packing of the B-DNA dodecamer d(ACCG-GCGCCACA).d(TGTGGCGCCGGT) is...
The role of microhydration in structural adjustments of the AT-tract in B-DNA was studied at the B97...
The synthetic deoxydodecamer d(C-G-C-G-A-A-T-T-A-G-C-G) was analyzed by x-ray diffraction methods, a...
The structure of the deoxyoligomer d(C-G-C-G-A-A-T-T-T-G-C-G) was determined at 2.5-A resolution by ...
The results of the search for low-energy conformations of poly(dA). poly(dT) and of the poly(dA).pol...
The physical configuration of double-stranded DNA plays a significant role in the protection and exp...
An analysis of the base pair doublet geometries in available crystal structures indicates that the o...
BACKGROUND: The flexibility of DNA enables it to adopt three interconvertible types of duplex termed...
Hydroxyl radicals are potent mutagens that attack DNA to form various base and ribose derivatives. O...
An analysis of the base pair doublet geometries in available crystal structures indicates that the o...