Ten-year survival results of a randomized trial of irradiation of internal mammary nodes after mastectomy.
- Hennequin, Christophe
- Bossard, Nadine
- Servagi-Vernat, Stéphanie
- Maingon, Philippe
- Dubois, Jean-Bernard
- Datchary, Jean
- Carrie, Christian
- Roullet, Bernard
- Suchaud, Jean-Philippe
- Teissier, Eric
- Lucardi, Audrey
- Gerard, Jean-Pierre
- Belot, Aurélien
- Iwaz, Jean
- Ecochard, René
- Romestaing, Pascale
DOIAbstract
PURPOSE: To evaluate the efficacy of irradiation of internal mammary nodes (IMN) on 10-year overall survival in breast cancer patients after mastectomy. METHODS AND PATIENTS: This multicenter phase 3 study enrolled patients with positive axillary nodes (pN+) or central/medial tumors with or without pN+. Other inclusion criteria were age <75 and a Karnofsky index ≥70. All patients received postoperative irradiation of the chest wall and supraclavicular nodes and were randomly assigned to receive IMN irradiation or not. Randomization was stratified by tumor location (medial/central or lateral), axillary lymph node status, and adjuvant therapy (chemotherapy vs no chemotherapy). The prescribed dose of irradiation to the target volumes was 50 Gy...
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