Novel distamycin analogues: facile synthesis of cholesterol conjugates of distamycin-like oligopeptides

A facile route towards the synthesis of the first examples of cholesterol-conjugated distamycin analogues is described. These compounds retain their strong binding capacity to double-stranded (ds)-DNA. Aqueous suspensions of these analogues exhibited closed, vesicle-like structures under transmission electron microscope. A facile route toward the synthesis of the first examples of cholesterol conjugates of distamycin is described