It is known that free fatty acid (FFA) contributes to the development of insulin resistance and type2 diabetes. However, the underlying mechanism in FFA-induced insulin resistance is still unclear. In the present investigation we have demonstrated that palmitate significantly (p < 0.001) inhibited insulin-stimulated phosphorylation of PDK1, the key insulin signaling molecule. Consequently, PDK1 phosphorylation of plasma membrane bound PKCε was also inhibited. Surprisingly, phosphorylation of cytosolic PKCε was greatly stimulated by palmitate; this was then translocated to the nuclear region and associated with the inhibition of insulin receptor (IR) gene transcription. A PKCε translocation inhibitor peptide, εV1, supp...
Obesity and type 2 diabetes mellitus (T2DM) are characterized by insulin resistance and impaired glu...
The decrease in insulin sensitivity to target tissues or insulin resistance leads to type 2 diabetes...
The decrease in insulin sensitivity to target tissues or insulin resistance leads to type 2 diabetes...
It is known that free fatty acid (FFA) contributes to the development of insulin resistance and type...
Fatty acids are known to play a key role in promoting the loss of insulin sensitivity causing insuli...
Fatty acids (FAs) are known to impair insulin signaling in target cells. Accumulating evidences sugg...
AbstractFatty acids (FAs) are known to impair insulin signaling in target cells. Accumulating eviden...
Free fatty acids are known to play a key role in promoting loss of insulin sensitivity, thereby caus...
AbstractFatty acids (FAs) are known to impair insulin signaling in target cells. Accumulating eviden...
Abnormalities in lipid metabolism have been proposed as con-tributing factors to both defective insu...
Macrophage-derived factors contribute to whole-body insulin resistance, partly by impinging on metab...
AbstractInsulin stimulates its own secretion and synthesis by pancreatic β-cells. Although the exact...
Non-esterified fatty acids (NEFAs) have been implicated in the pathogenesis of skeletal muscle insul...
Non-esterified fatty acids (NEFAs) have been implicated in the pathogenesis of skeletal muscle insul...
Non-esterified fatty acids (NEFAs) have been implicated in the pathogenesis of skeletal muscle insul...
Obesity and type 2 diabetes mellitus (T2DM) are characterized by insulin resistance and impaired glu...
The decrease in insulin sensitivity to target tissues or insulin resistance leads to type 2 diabetes...
The decrease in insulin sensitivity to target tissues or insulin resistance leads to type 2 diabetes...
It is known that free fatty acid (FFA) contributes to the development of insulin resistance and type...
Fatty acids are known to play a key role in promoting the loss of insulin sensitivity causing insuli...
Fatty acids (FAs) are known to impair insulin signaling in target cells. Accumulating evidences sugg...
AbstractFatty acids (FAs) are known to impair insulin signaling in target cells. Accumulating eviden...
Free fatty acids are known to play a key role in promoting loss of insulin sensitivity, thereby caus...
AbstractFatty acids (FAs) are known to impair insulin signaling in target cells. Accumulating eviden...
Abnormalities in lipid metabolism have been proposed as con-tributing factors to both defective insu...
Macrophage-derived factors contribute to whole-body insulin resistance, partly by impinging on metab...
AbstractInsulin stimulates its own secretion and synthesis by pancreatic β-cells. Although the exact...
Non-esterified fatty acids (NEFAs) have been implicated in the pathogenesis of skeletal muscle insul...
Non-esterified fatty acids (NEFAs) have been implicated in the pathogenesis of skeletal muscle insul...
Non-esterified fatty acids (NEFAs) have been implicated in the pathogenesis of skeletal muscle insul...
Obesity and type 2 diabetes mellitus (T2DM) are characterized by insulin resistance and impaired glu...
The decrease in insulin sensitivity to target tissues or insulin resistance leads to type 2 diabetes...
The decrease in insulin sensitivity to target tissues or insulin resistance leads to type 2 diabetes...