N Terminal-Pro Brain Natriuretic Peptide (Nt–ProBNP) Pada Penderita Hipertensi Derajat 1 Dan Derajat 2

The level of N Terminal – Pro Brain Natriuretic Peptide was independently associated with an increased risk of hypertension. This study aimed to determine the difference of NT-proBNP serum levels and the correlation between the levels of NT-proBNP in patients with hypertension stage 1 and stage 2. This research was conducted at RSUP dr. Wahidin Sudirohusodo in August -September 2018. The research was conducted at Dr. Wahidin Sudirohusodo RSUP from August through September 2018. The study used a cross-sectional design with a total of 72 hypertensive patients, who had met the inclusive criteria. NT-proBNP levels were measured using the ELISA (Enzyme-Linked Immunosorbent Assay) method.  The collected data is processed using Mann Whitney Different Test and Spearman's rho Correlation Test. The study results indicated that the level of NT-proBNP in the hypertensive patients with stage 2 (172.85 + 316.26) was higher and significantly different (p = <0.001) compared to hypertensive patients stage 1 (34.98 + 28.99). NT-proBNP levels were higher in the hypertensive group of >6 years (247.83+361.01) than in the hypertensive group <6 years (62.79+164.66), statistically there were significant differences between the two groups (p=0.010). There was in a significant correlation between the levels of NT-proBNP in hypertensive patients, stage 1 and stage 2 (p = 0.862) even though it showed significantly different results.Peningkatan kadar N Terminal-pro Brain Natriuretic Peptide (NT-proBNP) secara independen terkait dengan peningkatan risiko hipertensi. Penelitian ini bertujuan mengetahui perbedaan kadar NT-proBNP serum dan hubungan kadar NT-proBNP pada penderita Hipertensi Derajat 1 dan Derajat 2. Penelitian ini dilakukan di RSUP dr. Wahidin Sudirohusodo pada bulan Agustus -September 2018. Penelitian ini menggunakan desain cross sectional dengan jumlah pasien Hipertensi sebanyak 72 orang yang memenuhi kriteria inklusi.Kadar NT-proBNP diukur dengan menggunakan metoda ELISA (Enzyme Linked Immunosorbent Assay). Data yang terkumpul diolah dengan uji beda Mann Whithney, Spearman’s rho.Hasil penelitian menunjukan kadar NT-proBNP pada penderita hipertensi derajat 2 (172.85+316.26) lebih tinggi dan berbeda bermakna (p=<0,001) dibandingkan hipertensi derajat 1 (34.98+28.99). Kadar NT-proBNP lebih tinggi pada kelompok penderita hipertensi >6 tahun (247.83+361.01) dibandingkan kelompok penderita hipertensi <6 tahun (62.79+164.66), secara statistik ada perbedaan yang bermakna antara kedua kelompok tersebut (p=0,010). Disimpulkan bahwa tidak ada hubungaan yang bermakna kadar NT-proBNP pada penderita hipertensi derajat 1 dan derajat 2 (p=0.862) walaupun menunjukan hasil berbeda bermakna