A short and efficient synthetic strategy for the total syntheses of (S)-(+)-and (R)-(−)-plakolide A

Concise and efficient total syntheses of anticancer agents (S)-(+)-Plakolide A and (R)-(−)-Plakolide A were accomplished in eight steps and an overall yield of 39% starting from geraniol. The key steps in our strategy are Sharpless asymmetric epoxidation, double elimination, and Stille coupling reactions