We report herein the design, synthesis, and transfection biology of a novel series of non-glycerol-based cationic lipids with lactic acid-derived head groups The synthetic procedure adopted herein for preparing 1-hydroxy-prop-2-yl head-group-based monocationic transfection lipids 1-7 is fairly straightforward and potentially applicable in designing other cationic lipids with lactic acid-derived head groups. A striking anchor-length dependency was observed in NIH3T3 cells in the sense that except lipid 4, all the other lipids were essentially transfection-inefficient. Ethidium bromide assay for the lipid:DNA interactions is consistent with the general observation that significant lipid:DNA interactions do not guarantee on improved transfecti...
International audienceCationic lipids constitute a family of synthetic vectors commonly used for nuc...
AbstractBackground: Although synthetic nonviral vectors hold promise for the delivery of plasmid DNA...
The clinical success of gene therapy is critically dependent on the development of efficient and saf...
The molecular structure of the cationic lipids used in gene transfection strongly influences their t...
Detailed structure-activity investigations aimed at probing the anchor chain length dependency for g...
A novel series of nontoxic and non-glycerol-based simple monocationic transfection lipids containing...
AbstractDetailed structure–activity investigations aimed at probing the anchor chain length dependen...
The design of efficacious cationic transfection lipids with guanidinium headgroups is an actively pu...
Although detailed structure-activity, physicochemical and biophysical investigations in probing the ...
Non–viral gene vectors exhibit several desirable properties, over their viral counterparts. This has...
International audienceOver the last several years, various gene delivery systems have been developed...
Structure-activity investigation including design, syntheses, and evaluation of relative in vitro ge...
The design, synthesis and biological evaluation of the cationic lipid gene delivery vectors based on...
Lipid-mediated delivery of DNA into cells holds great promise both for gene therapy and basic resear...
Recent rapid developments in genomics will likely lead to a rapid expansion in identifying defective...
International audienceCationic lipids constitute a family of synthetic vectors commonly used for nuc...
AbstractBackground: Although synthetic nonviral vectors hold promise for the delivery of plasmid DNA...
The clinical success of gene therapy is critically dependent on the development of efficient and saf...
The molecular structure of the cationic lipids used in gene transfection strongly influences their t...
Detailed structure-activity investigations aimed at probing the anchor chain length dependency for g...
A novel series of nontoxic and non-glycerol-based simple monocationic transfection lipids containing...
AbstractDetailed structure–activity investigations aimed at probing the anchor chain length dependen...
The design of efficacious cationic transfection lipids with guanidinium headgroups is an actively pu...
Although detailed structure-activity, physicochemical and biophysical investigations in probing the ...
Non–viral gene vectors exhibit several desirable properties, over their viral counterparts. This has...
International audienceOver the last several years, various gene delivery systems have been developed...
Structure-activity investigation including design, syntheses, and evaluation of relative in vitro ge...
The design, synthesis and biological evaluation of the cationic lipid gene delivery vectors based on...
Lipid-mediated delivery of DNA into cells holds great promise both for gene therapy and basic resear...
Recent rapid developments in genomics will likely lead to a rapid expansion in identifying defective...
International audienceCationic lipids constitute a family of synthetic vectors commonly used for nuc...
AbstractBackground: Although synthetic nonviral vectors hold promise for the delivery of plasmid DNA...
The clinical success of gene therapy is critically dependent on the development of efficient and saf...