Classification, dimensionality reduction, and maximally discriminatory visualization of a multicentre 1H-MRS database of brain tumors

The combination of an Artificial Neural Network classifier, a feature selection process, and a novel linear dimensionality reduction technique that provides a data projection for visualization and which preserves completely the class discrimination achieved by the classifier, is applied in this study to the analysis of an international, multi-centre 1H-MRS database of brain tumors. This combination yields results that are both intuitively interpretable and very accurate. The method as a whole remains simple enough as to allow its easy integration in existing medical decision support systems.Peer Reviewe