Enantiomer-selective molecular sensing using racemic nanoplasmonic arrays

This document is the unedited Author’s version of a Submitted Work that was subsequently accepted for publication in Nano Letters, copyright © American Chemical Society after peer review. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acs.nanolett.8b02433, see http://pubs.acs.org/page/policy/articlesonrequest/index.htmlBuilding blocks of life show well-defined chiral symmetry which has a direct influence on their properties and role in Nature. Chiral molecules are typically characterized by optical techniques such as circular dichroism (CD) where they exhibit signatures in the ultraviolet frequency region. Plasmonic nanostructures have the potential to enhance the sensitivity of chiral detection and translate the molecular chirality to the visible spectral range. Despite recent progress, to date, it remains unclear which properties plasmonic sensors should exhibit to maximize this effect and apply it to reliable enantiomer discrimination. Here, we bring further insight into this complex problem and present a chiral plasmonic sensor composed of a racemic mixture of gammadions with no intrinsic CD, but high optical chirality and electric field enhancements in the near-fields. Owing to its unique set of properties, this configuration enables us to directly differentiate phenylalanine enantiomers in the visible frequency range.Peer Reviewe