Add to ORKGDespite the effectiveness of antiretroviral medication, the HIV virus persists in resting memory T cells of infected patients in a latent state, providing the main impediment to eradication of the virus. We are interested in identifying the molecular mechanism responsible for the establishment and maintenance of HIV latency and its re-activation. We recently used a cell system reflecting HIV latency in my lab to determine the high resolution nucleosomal landscape of the latent HIV LTR and examine its dynamic changes upon re-activation (Rafati et al., Nov 2011 PLoS Biology)..
HIV latency is a major obstacle to curing infection. Current strategies to eradicate HIV aim at incr...
HIV establishes a latent reservoir in a small pool of resting CD4+ T cells early in the infection of...
Despite ongoing efforts, HIV-1 (the causative agent of AIDS) remains an unresolved health threat. Ev...
Despite the effectiveness of antiretroviral medication, the HIV virus persists in resting memory T ...
Abstract Latently infected cells represent the major barrier to either a sterilizing or a functional...
Aids has become the leading cause of death world-wide. Much research has been done on the causal age...
Abstract The persistence of HIV-1 latent reservoirs represents a major barrier to virus eradication ...
AbstractReplication-competent latent HIV-1 proviruses that persist in the genomes of a very small su...
Current antiretroviral therapies fail to cure HIV-1 (human immunodeficiency virus type 1) infection ...
Highly active antiretroviral therapy (HAART) in individuals infected with HIV-1 often lowers plasma ...
Combination antiretroviral therapy, despite being potent and life-prolonging, is not curative and do...
The introduction of highly active antiretroviral therapy (HAART) has been an important breakthrough ...
Background\ud Latent HIV-1 reservoirs are identified as one of the major challenges to achieve HIV-1...
HIV/AIDS is undoubtedly one of mankind’s most pressing health concerns. Currently, there are ~34 mil...
Background: Molecular latency allows HIV-1 to persist in resting memory CD4+ T-cell...
HIV latency is a major obstacle to curing infection. Current strategies to eradicate HIV aim at incr...
HIV establishes a latent reservoir in a small pool of resting CD4+ T cells early in the infection of...
Despite ongoing efforts, HIV-1 (the causative agent of AIDS) remains an unresolved health threat. Ev...
Despite the effectiveness of antiretroviral medication, the HIV virus persists in resting memory T ...
Abstract Latently infected cells represent the major barrier to either a sterilizing or a functional...
Aids has become the leading cause of death world-wide. Much research has been done on the causal age...
Abstract The persistence of HIV-1 latent reservoirs represents a major barrier to virus eradication ...
AbstractReplication-competent latent HIV-1 proviruses that persist in the genomes of a very small su...
Current antiretroviral therapies fail to cure HIV-1 (human immunodeficiency virus type 1) infection ...
Highly active antiretroviral therapy (HAART) in individuals infected with HIV-1 often lowers plasma ...
Combination antiretroviral therapy, despite being potent and life-prolonging, is not curative and do...
The introduction of highly active antiretroviral therapy (HAART) has been an important breakthrough ...
Background\ud Latent HIV-1 reservoirs are identified as one of the major challenges to achieve HIV-1...
HIV/AIDS is undoubtedly one of mankind’s most pressing health concerns. Currently, there are ~34 mil...
Background: Molecular latency allows HIV-1 to persist in resting memory CD4+ T-cell...
HIV latency is a major obstacle to curing infection. Current strategies to eradicate HIV aim at incr...
HIV establishes a latent reservoir in a small pool of resting CD4+ T cells early in the infection of...
Despite ongoing efforts, HIV-1 (the causative agent of AIDS) remains an unresolved health threat. Ev...