Add to ORKGAn unexpected C-C bond cleavage was observed in trichloroacetamide-tethered ketones under amine treatment and exploited to develop a new synthesis of normophans from 4-amidocyclohexanones. The reaction involves an unprecedented intramolecular haloform-type reaction of trichloroacetamides promoted by enamines (generated in situ from ketones) as counter-reagents. The methodology was applied to the synthesis of compounds embodying the 6-azabicyclo[3.2.1]octane framework
Copyright © 2019 American Chemical Society. Described herein is the development of a new entry of ac...
Typescript (photocopy).The cyclization of the benzyl carbamate of 6-hepten-2-amine (31) with mercuri...
Cycloaddition reactions are powerful transformations for the construction of various cyclic organic ...
An unexpected C-C bond cleavage was observed in trichloroacetamide-tethered ketones under amine trea...
An unexpected C–C bond cleavage was observed in trichloroacetamide-tethered ketones under amine trea...
An unusual reaction is described, involving a formal intramolecular nucleophilic substitution of bro...
An attractive strategy for the synthesis of saturated nitrogen-containing heterocycles is described ...
The 6-azabicyclo[3.2.1]octane has been of great interest for medicinal chemists for some time now. S...
The synthesis of the 6-azabicyclo[3.2.1]octane ring system, via Dieckmann cyclization, is described....
Two novel approaches to key intermediates for carbapenem synthesis were investigated. The first empl...
The 6-azabicyclo[3.2.1]octane ring system, prevalent in a range of biologically active molecules, is...
Reported herein is the development of rhodium-catalyzed intramolecular amido transfer as an efficien...
An efficient and straightforward approach for the synthesis of carbamoylated chroman-4-ones has been...
Multicomponent reactions provide simple and convergent paths to structurally complex products in ato...
Bridged nitrogen bicyclic skeletons have been accessed via unprecedented site- and diastereoselectiv...
Copyright © 2019 American Chemical Society. Described herein is the development of a new entry of ac...
Typescript (photocopy).The cyclization of the benzyl carbamate of 6-hepten-2-amine (31) with mercuri...
Cycloaddition reactions are powerful transformations for the construction of various cyclic organic ...
An unexpected C-C bond cleavage was observed in trichloroacetamide-tethered ketones under amine trea...
An unexpected C–C bond cleavage was observed in trichloroacetamide-tethered ketones under amine trea...
An unusual reaction is described, involving a formal intramolecular nucleophilic substitution of bro...
An attractive strategy for the synthesis of saturated nitrogen-containing heterocycles is described ...
The 6-azabicyclo[3.2.1]octane has been of great interest for medicinal chemists for some time now. S...
The synthesis of the 6-azabicyclo[3.2.1]octane ring system, via Dieckmann cyclization, is described....
Two novel approaches to key intermediates for carbapenem synthesis were investigated. The first empl...
The 6-azabicyclo[3.2.1]octane ring system, prevalent in a range of biologically active molecules, is...
Reported herein is the development of rhodium-catalyzed intramolecular amido transfer as an efficien...
An efficient and straightforward approach for the synthesis of carbamoylated chroman-4-ones has been...
Multicomponent reactions provide simple and convergent paths to structurally complex products in ato...
Bridged nitrogen bicyclic skeletons have been accessed via unprecedented site- and diastereoselectiv...
Copyright © 2019 American Chemical Society. Described herein is the development of a new entry of ac...
Typescript (photocopy).The cyclization of the benzyl carbamate of 6-hepten-2-amine (31) with mercuri...
Cycloaddition reactions are powerful transformations for the construction of various cyclic organic ...