AIM: To assess HER-2 and p-AKT expression in upper urinary tract urothelial carcinoma (UTUC) in order to determine their value as prognostic factors of tumour progression and cancer-specific survival. PATIENTS AND METHODS: One hundred consecutive UTUC patients were retrospectively included, between 1990-2004, in 4 tissue microarrays for immunostaining. Median follow-up: 33.03 months. RESULTS: Positive HER-2 expression was found in 10 cases and cytoplasmic p-AKT expression in 84 cases; the expression intensity was strong: 30 cases, moderate: 28 and weak: 26. Nuclear p-AKT expression was found in 6 patients: 1 with strong, and 5 with moderate intensity. Nuclear p-AKT expression was an independent factor for tumour progression (HR=4.145, p=0.0...
The generation of urothelial carcinoma is caused by the accumulation of various molecular changes, a...
AbstractUpper tract urothelial carcinomas are tumors derived from urothelium along the urinary tract...
Objectives: To evaluate if the Human epidermal growth factor receptor 2 (HER-2) expression levels ma...
AIM: To assess HER-2 and p-AKT expression in upper urinary tract urothelial carcinoma (UTUC) in orde...
AbstractObjectiveSeveral studies have explored the prognostic values of HER2 expression in upper tra...
Objective: Several studies have explored the prognostic values of HER2 expression in upper tract uro...
The aim of our study was to evaluate the expression pattern of HER2 overexpression in patients with ...
Background. Several investigators have suggested the possibility that the expression of both EGFR an...
We evaluated primary tumors from two cohorts, Spain (N = 111) and Greece (N = 102), for patients who...
AbstractThis study assessed the human epidermal growth factor receptor-2 (HER2) protein expression i...
Introduction: Overexpression and the amplification of proto-oncogenic c-erythroblastic oncogene B (c...
Background/Aim. Deregulation of the normal cell cycle is common in upper urothelial carcinoma (UUC)...
ABSTRACT Upper tract urothelial carcinoma (UTUC) is a rare and aggressive disease that is associated...
Background: In recent years, HER2 amplification has been evaluated as a potential prognostic biomark...
The generation of urothelial carcinoma is caused by the accumulation of various molecular changes, a...
The generation of urothelial carcinoma is caused by the accumulation of various molecular changes, a...
AbstractUpper tract urothelial carcinomas are tumors derived from urothelium along the urinary tract...
Objectives: To evaluate if the Human epidermal growth factor receptor 2 (HER-2) expression levels ma...
AIM: To assess HER-2 and p-AKT expression in upper urinary tract urothelial carcinoma (UTUC) in orde...
AbstractObjectiveSeveral studies have explored the prognostic values of HER2 expression in upper tra...
Objective: Several studies have explored the prognostic values of HER2 expression in upper tract uro...
The aim of our study was to evaluate the expression pattern of HER2 overexpression in patients with ...
Background. Several investigators have suggested the possibility that the expression of both EGFR an...
We evaluated primary tumors from two cohorts, Spain (N = 111) and Greece (N = 102), for patients who...
AbstractThis study assessed the human epidermal growth factor receptor-2 (HER2) protein expression i...
Introduction: Overexpression and the amplification of proto-oncogenic c-erythroblastic oncogene B (c...
Background/Aim. Deregulation of the normal cell cycle is common in upper urothelial carcinoma (UUC)...
ABSTRACT Upper tract urothelial carcinoma (UTUC) is a rare and aggressive disease that is associated...
Background: In recent years, HER2 amplification has been evaluated as a potential prognostic biomark...
The generation of urothelial carcinoma is caused by the accumulation of various molecular changes, a...
The generation of urothelial carcinoma is caused by the accumulation of various molecular changes, a...
AbstractUpper tract urothelial carcinomas are tumors derived from urothelium along the urinary tract...
Objectives: To evaluate if the Human epidermal growth factor receptor 2 (HER-2) expression levels ma...