Add to ORKGIntellectual disability is the most limiting hallmark of Down syndrome, for which there is no gold-standard clinical treatment yet. The endocannabinoid system is a widespread neuromodulatory system involved in multiple functions including learning and memory processes. Alterations of this system contribute to the pathogenesis of several neurological and neurodevelopmental disorders. However, the involvement of the endocannabinoid system in the pathogenesis of Down syndrome has not been explored before. We used the best-characterized preclinical model of Down syndrome, the segmentally trisomic Ts65Dn model. In male Ts65Dn mice, cannabinoid type-1 receptor (CB1R) expression was enhanced and its function increased in hippocampal excitatory ter...
Fragile X syndrome (FXS) is the most common monogenetic cause of intellectual disability. The cognit...
Down syndrome (DS) is a genetic condition caused by the triplication of chromosome 21. The most inva...
Neurodevelopmental alterations and cognitive disability are constant features of Down syndrome (DS),...
Intellectual disability is the most limiting hallmark of Down syndrome, for which there is no gold-s...
International audienceDown syndrome (DS) or Trisomy 21 is the most common genetic cause of mental re...
Tutors: Andrés Ozaita Mintegui, Anna Vázquez OliverDown syndrome (DS) is the most common cause of in...
Fragile X syndrome (FXS) is the most common monogenetic cause of intellectual disability. The cognit...
Intellectual disability encompasses several neurodevelopmental disorders characterized by impairment...
Down syndrome (DS) is the most frequent genetic cause of intellectual disability, and altered GABAer...
Fragile X syndrome (FXS), the most common monogenic cause of inherited intellectual disability and a...
Down syndrome (DS) is associated with neurological complications, including cognitive deficits that ...
Down syndrome (DS) is associated with neurological complications, including cognitive deficits that ...
Intellectual disability is the unavoidable hallmark of Down syndrome (DS), with a heavy impact on pu...
Background: Recent evidence suggests that 2-week treatment with the non-psychotomimetic cannabinoid ...
Trisomy 21 or Down syndrome (DS) is the most common cause of intellectual disability of a genetic or...
Fragile X syndrome (FXS) is the most common monogenetic cause of intellectual disability. The cognit...
Down syndrome (DS) is a genetic condition caused by the triplication of chromosome 21. The most inva...
Neurodevelopmental alterations and cognitive disability are constant features of Down syndrome (DS),...
Intellectual disability is the most limiting hallmark of Down syndrome, for which there is no gold-s...
International audienceDown syndrome (DS) or Trisomy 21 is the most common genetic cause of mental re...
Tutors: Andrés Ozaita Mintegui, Anna Vázquez OliverDown syndrome (DS) is the most common cause of in...
Fragile X syndrome (FXS) is the most common monogenetic cause of intellectual disability. The cognit...
Intellectual disability encompasses several neurodevelopmental disorders characterized by impairment...
Down syndrome (DS) is the most frequent genetic cause of intellectual disability, and altered GABAer...
Fragile X syndrome (FXS), the most common monogenic cause of inherited intellectual disability and a...
Down syndrome (DS) is associated with neurological complications, including cognitive deficits that ...
Down syndrome (DS) is associated with neurological complications, including cognitive deficits that ...
Intellectual disability is the unavoidable hallmark of Down syndrome (DS), with a heavy impact on pu...
Background: Recent evidence suggests that 2-week treatment with the non-psychotomimetic cannabinoid ...
Trisomy 21 or Down syndrome (DS) is the most common cause of intellectual disability of a genetic or...
Fragile X syndrome (FXS) is the most common monogenetic cause of intellectual disability. The cognit...
Down syndrome (DS) is a genetic condition caused by the triplication of chromosome 21. The most inva...
Neurodevelopmental alterations and cognitive disability are constant features of Down syndrome (DS),...