Add to ORKGWe have targeted a K-ras allele in mouse embryonic stem (ES) cells to express a K-Ras(V12) oncoprotein along with a marker protein (beta-geo) from a single bicistronic transcript. Expression of this oncogenic allele requires removal of a knocked in STOP transcriptional cassette by Cre recombinase. Primary mouse embryonic fibroblasts expressing this K-ras(V12) allele do not undergo proliferative senescence and proliferate as immortal cells. In mice, expression of K-ras(V12) throughout the body fails to induce unscheduled proliferation or other growth abnormalities for up to eight months. Only a percentage of K-ras(V12)-expressing lung bronchiolo-alveolar cells undergo malignant transformation leading to the formation of multiple adenomas and...
Cancer is defined as the abnormal proliferation of cells. This has become an important disease over ...
Induction of pluripotency in somatic cells with defined genetic factors has been successfully used t...
BACKGROUND & OBJECTIVES: Ras gene plays an important role in the extra- and intra-cellular signal tr...
We have targeted a K-ras allele in mouse embryonic stem (ES) cells to express a K-Ras(V12) oncoprote...
AbstractWe have targeted a K-ras allele in mouse embryonic stem (ES) cells to express a K-RasV12 onc...
AbstractActivating mutations in the ras oncogene are not considered sufficient to induce abnormal ce...
Genetic studies in mice have provided evidence that H-Ras and K-Ras proteins are bioequivalent. Howe...
Mutation of K-Ras is a frequent oncogenic event in human cancers, particularly cancers of lungs, pan...
Ubiquitous expression of a resident K-RasG12V oncogene in adult mice revealed that most tissues are ...
Genetic studies in mice have provided evidence that H-Ras and K-Ras proteins are bioequivalent. Howe...
Ras proteins transduce signals from membrane-bound receptors via multiple downstream effector pathwa...
To examine the roles of endogenous K-ras 4A and K-ras 4B splice variants in tumorigenesis, murine lu...
Ras proteins transduce signals from membrane-bound receptors via multiple downstream effector pathwa...
The current model for cancer development envisions cells undergoing a series of genetic mutations an...
Different mutant amino acids in the Ras proteins lead to distinct transforming capacities and differ...
Cancer is defined as the abnormal proliferation of cells. This has become an important disease over ...
Induction of pluripotency in somatic cells with defined genetic factors has been successfully used t...
BACKGROUND & OBJECTIVES: Ras gene plays an important role in the extra- and intra-cellular signal tr...
We have targeted a K-ras allele in mouse embryonic stem (ES) cells to express a K-Ras(V12) oncoprote...
AbstractWe have targeted a K-ras allele in mouse embryonic stem (ES) cells to express a K-RasV12 onc...
AbstractActivating mutations in the ras oncogene are not considered sufficient to induce abnormal ce...
Genetic studies in mice have provided evidence that H-Ras and K-Ras proteins are bioequivalent. Howe...
Mutation of K-Ras is a frequent oncogenic event in human cancers, particularly cancers of lungs, pan...
Ubiquitous expression of a resident K-RasG12V oncogene in adult mice revealed that most tissues are ...
Genetic studies in mice have provided evidence that H-Ras and K-Ras proteins are bioequivalent. Howe...
Ras proteins transduce signals from membrane-bound receptors via multiple downstream effector pathwa...
To examine the roles of endogenous K-ras 4A and K-ras 4B splice variants in tumorigenesis, murine lu...
Ras proteins transduce signals from membrane-bound receptors via multiple downstream effector pathwa...
The current model for cancer development envisions cells undergoing a series of genetic mutations an...
Different mutant amino acids in the Ras proteins lead to distinct transforming capacities and differ...
Cancer is defined as the abnormal proliferation of cells. This has become an important disease over ...
Induction of pluripotency in somatic cells with defined genetic factors has been successfully used t...
BACKGROUND & OBJECTIVES: Ras gene plays an important role in the extra- and intra-cellular signal tr...