The biological responses of human haematopoietic cells of myeloid lineage following malignant transformation depends crucially on their adaptation to signalling stress. This adaptation is dependent on the activation of the hypoxia-inducible factor 1 (HIF-1) transcription complex, although the mechanisms underlying its control remain unclear. Here, we report that mammalian target of rapamycin (mTOR) kinase, a central regulator of myeloid cell growth and metabolism, is crucially involved in HIF-1α accumulation/HIF-1 activation in human THP-1 myeloid monocytes, LAD2 mast cells and primary basophils in a variety of different settings. In THP-1 cells, mTOR was a major contributor to HIF-1 activation induced by ligands of both membrane-associated...
Accumulation of HIF-1alpha during normoxic conditions at high cell density has previously been shown...
The serine/threonine protein kinase mechanistic target of rapamycin (mTOR) has been implicated in th...
Mammalian target of rapamycin (mTOR) is a conserved serine/threonine kinase that integrates signals ...
The biological responses of human haematopoietic cells of myeloid lineage following malignant transf...
We recently showed that hypoxia-inducible factor 1 (HIF-1) plays a crucial role in the pro-allergic ...
Mammalian myeloid cells are crucial effectors of host innate immune defense. Normal and pathological...
Mammalian myeloid cells are crucial effectors of host innate immune defense. Normal and pathological...
Human inflammatory/innate immune responses lie at the core of resistance to infectious disease and d...
HIF1A is a transcription factor that plays a central role for the adaptation to tissue hypoxia and f...
Stem cell factor (SCF) is a hematopoietic growth factor that exerts its activity by signalling throu...
Potential crosslinks between inflammation and leukaemia have been discussed for some time, but exper...
The target of rapamycin (TOR) is a high molecular weight protein kinase that regulates many processe...
HIF1A is a transcription factor that plays a central role for the adaptation to tissue hypoxia and f...
With little in the way of effective therapeutic strategies to target the innate immune response, a b...
The mechanistic target of rapamycin (mTOR) pathway integrates diverse environmental inputs, includin...
Accumulation of HIF-1alpha during normoxic conditions at high cell density has previously been shown...
The serine/threonine protein kinase mechanistic target of rapamycin (mTOR) has been implicated in th...
Mammalian target of rapamycin (mTOR) is a conserved serine/threonine kinase that integrates signals ...
The biological responses of human haematopoietic cells of myeloid lineage following malignant transf...
We recently showed that hypoxia-inducible factor 1 (HIF-1) plays a crucial role in the pro-allergic ...
Mammalian myeloid cells are crucial effectors of host innate immune defense. Normal and pathological...
Mammalian myeloid cells are crucial effectors of host innate immune defense. Normal and pathological...
Human inflammatory/innate immune responses lie at the core of resistance to infectious disease and d...
HIF1A is a transcription factor that plays a central role for the adaptation to tissue hypoxia and f...
Stem cell factor (SCF) is a hematopoietic growth factor that exerts its activity by signalling throu...
Potential crosslinks between inflammation and leukaemia have been discussed for some time, but exper...
The target of rapamycin (TOR) is a high molecular weight protein kinase that regulates many processe...
HIF1A is a transcription factor that plays a central role for the adaptation to tissue hypoxia and f...
With little in the way of effective therapeutic strategies to target the innate immune response, a b...
The mechanistic target of rapamycin (mTOR) pathway integrates diverse environmental inputs, includin...
Accumulation of HIF-1alpha during normoxic conditions at high cell density has previously been shown...
The serine/threonine protein kinase mechanistic target of rapamycin (mTOR) has been implicated in th...
Mammalian target of rapamycin (mTOR) is a conserved serine/threonine kinase that integrates signals ...