Capsular polysaccharides (CPSs) are essential virulence determinants of many pathogenic bacteria. Escherichia coli group 1 CPSs provide paradigms for widespread surface polysaccharide assembly systems in Gram-negative bacteria. In these systems, complex carbohydrate polymers must be exported across the periplasm and outer membrane to the cell surface. Group 1 CPS export requires oligomers of the outer membrane protein, Wza, for translocation across the outer membrane. Assembly also depends on Wzc, an inner membrane tyrosine autokinase known to regulate export and synthesis of group 1 CPS. Here, we provide a structural view of a complex comprising Wzc and Wza that spans the periplasm, connecting the inner and outer membranes. Examination of ...
Lipopolysaccharide (LPS) is an essential component of the outer membrane (OM) in most gram-negative ...
Lipopolysaccharide (LPS) is an essential component of the outer membrane (OM) in most gram-negative ...
SummaryMany pathogenic bacteria encase themselves in a polysaccharide capsule that provides a barrie...
Capsular polysaccharides (CPSs) are essential virulence determinants of many pathogenic bacteria. Es...
Many types of bacteria produce extracellular polysaccharides (EPSs). Some are secreted polymers and ...
The K antigenic capsular polysaccharide forms a structural layer, the capsule, on the surfaces of Es...
The K antigenic capsular polysaccharide forms a structural layer, the capsule, on the surfaces of Es...
The late steps in assembly of capsular polysaccharides (CPS) and their translocation to the bacteria...
The late steps in assembly of capsular polysaccharides (CPS) and their translocation to the bacteria...
The cell surface expression of group 2 capsular polysaccharides involves the translocation of the po...
Wza is a highly conserved multimeric outer membrane protein complex required for the surface express...
Wza is a highly conserved multimeric outer membrane protein complex required for the surface express...
Escherichia coli group 1 K antigens form a tightly associated capsule structure on the cell surface....
Capsules are surface layers of hydrated capsular polysaccharides (CPSs) produced by many bacteria. T...
Capsules are surface layers of hydrated capsular polysaccharides (CPSs) produced by many bacteria. T...
Lipopolysaccharide (LPS) is an essential component of the outer membrane (OM) in most gram-negative ...
Lipopolysaccharide (LPS) is an essential component of the outer membrane (OM) in most gram-negative ...
SummaryMany pathogenic bacteria encase themselves in a polysaccharide capsule that provides a barrie...
Capsular polysaccharides (CPSs) are essential virulence determinants of many pathogenic bacteria. Es...
Many types of bacteria produce extracellular polysaccharides (EPSs). Some are secreted polymers and ...
The K antigenic capsular polysaccharide forms a structural layer, the capsule, on the surfaces of Es...
The K antigenic capsular polysaccharide forms a structural layer, the capsule, on the surfaces of Es...
The late steps in assembly of capsular polysaccharides (CPS) and their translocation to the bacteria...
The late steps in assembly of capsular polysaccharides (CPS) and their translocation to the bacteria...
The cell surface expression of group 2 capsular polysaccharides involves the translocation of the po...
Wza is a highly conserved multimeric outer membrane protein complex required for the surface express...
Wza is a highly conserved multimeric outer membrane protein complex required for the surface express...
Escherichia coli group 1 K antigens form a tightly associated capsule structure on the cell surface....
Capsules are surface layers of hydrated capsular polysaccharides (CPSs) produced by many bacteria. T...
Capsules are surface layers of hydrated capsular polysaccharides (CPSs) produced by many bacteria. T...
Lipopolysaccharide (LPS) is an essential component of the outer membrane (OM) in most gram-negative ...
Lipopolysaccharide (LPS) is an essential component of the outer membrane (OM) in most gram-negative ...
SummaryMany pathogenic bacteria encase themselves in a polysaccharide capsule that provides a barrie...